Human papillomavirus vaccine effectiveness within a cervical cancer screening programme: cohort study

C. Acuti Martellucci, S. Nomura, D. Yoneoka, P. Ueda, J.M.L. Brotherton, K. Canfell, M. Palmer, L. Manzoli, P. Giorgi Rossi, A. De Togni, C. Palmonari, A. Califano, E. Saito, M. Hashizume, K. Shibuya

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: To assess the effectiveness of an HPV vaccination programme in reducing the risk of cervical abnormalities identified at subsequent screening. Design: Retrospective cohort study using administrative health data. Setting: General population of Ferrara Province, Italy. Population: Female residents born in 1986–1993 and participating in the organized cervical screening programme in 2011–2018, who were eligible for HPV vaccination in catch-up cohorts. Methods: Logistic regression to evaluate the potential association between abnormal cervical cytology and one, two, three or at least one dose of HPV vaccine. Main outcome measures: Cervical abnormalities, as predicted by low-grade or high-grade cytology, by number of vaccine doses, stratified by age. Results: The sample consisted of 7785 women (mean age 27.5 years, SD 2.3). Overall, 391 (5.0%) were vaccinated with ≥1 dose and 893 (11.5%) had abnormal cytology. Women receiving at least one vaccine dose were significantly less likely to have an abnormal cytology (adjusted odds ratio 0.52; 95% confidence interval 0.34–0.79). Similar results were observed for women receiving a single dose, for both bivalent and quadrivalent vaccines, and applying buffer periods (excluding cytological outcomes within 1 month, 6 months and 1 year of the first dose). Conclusions: In the context of an organised cervical screening programme in Italy, catch-up HPV vaccination almost halved the risk of cytological abnormalities. Tweetable abstract: Among Ferrara women, vaccination against human papillomavirus halved the risk of screening cervical abnormalities. © 2020 Royal College of Obstetricians and Gynaecologists
Original languageEnglish
Pages (from-to)532-539
Number of pages8
JournalBJOG Int. J. Obstet. Gynaecol.
Volume128
Issue number3
DOIs
Publication statusE-pub ahead of print - Aug 10 2020

Keywords

  • Cervical screening
  • human papillomavirus
  • vaccine
  • Wart virus vaccine
  • adult
  • early cancer diagnosis
  • female
  • human
  • Italy
  • middle aged
  • papillomavirus infection
  • preventive health service
  • retrospective study
  • statistical model
  • treatment outcome
  • uterine cervix
  • uterine cervix tumor
  • virology
  • Adult
  • Cervix Uteri
  • Early Detection of Cancer
  • Female
  • Humans
  • Immunization Programs
  • Logistic Models
  • Middle Aged
  • Papillomavirus Infections
  • Papillomavirus Vaccines
  • Retrospective Studies
  • Treatment Outcome
  • Uterine Cervical Neoplasms

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