Human peripheral blood granulocytes and myeloid leukemic cell lines express both transcripts encoding for stem cell factor

U. Ramenghi, L. Ruggieri, I. Dianzani, C. Rosso, M. F. Brizzi, C. Camaschella, T. Pietsch, G. Saglio

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Stem cell factor (SCF), the ligand for the c-kit proto-oncogene, has been shown to play a critical role in the migration of melanocytes and germ cells during embryogenesis as well as in the proliferative control of the hematopoietic compartment. In this study we investigated the expression of both the soluble and transmembrane SCF forms in purified peripheral blood populations and in several hematopoietic cell lines. Expression of both transcripts, though in different ratios, was identified in whole bone marrow, in bone marrow stromal cells and in human peripheral blood. In peripheral blood, SCF expression could be ascribable to polymorphonuclear leukocytes (PMN), whereas no SCF expression was detected in isolated lymphocytes, monocytes and in some T lymphoid cell lines. Conversely, some hematopoietic myeloid cell lines, such as HL-60, KG1 and K562, express SCF with similar patterns.

Original languageEnglish
Pages (from-to)521-526
Number of pages6
JournalStem Cells
Volume12
Issue number5
Publication statusPublished - 1994

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Stem Cell Factor
Myeloid Cells
Granulocytes
Cell Line
Lymphocytes
Proto-Oncogenes
Melanocytes
Mesenchymal Stromal Cells
Germ Cells
Embryonic Development
Monocytes
Neutrophils
Bone Marrow
Population

ASJC Scopus subject areas

  • Cell Biology

Cite this

Ramenghi, U., Ruggieri, L., Dianzani, I., Rosso, C., Brizzi, M. F., Camaschella, C., ... Saglio, G. (1994). Human peripheral blood granulocytes and myeloid leukemic cell lines express both transcripts encoding for stem cell factor. Stem Cells, 12(5), 521-526.

Human peripheral blood granulocytes and myeloid leukemic cell lines express both transcripts encoding for stem cell factor. / Ramenghi, U.; Ruggieri, L.; Dianzani, I.; Rosso, C.; Brizzi, M. F.; Camaschella, C.; Pietsch, T.; Saglio, G.

In: Stem Cells, Vol. 12, No. 5, 1994, p. 521-526.

Research output: Contribution to journalArticle

Ramenghi, U, Ruggieri, L, Dianzani, I, Rosso, C, Brizzi, MF, Camaschella, C, Pietsch, T & Saglio, G 1994, 'Human peripheral blood granulocytes and myeloid leukemic cell lines express both transcripts encoding for stem cell factor', Stem Cells, vol. 12, no. 5, pp. 521-526.
Ramenghi, U. ; Ruggieri, L. ; Dianzani, I. ; Rosso, C. ; Brizzi, M. F. ; Camaschella, C. ; Pietsch, T. ; Saglio, G. / Human peripheral blood granulocytes and myeloid leukemic cell lines express both transcripts encoding for stem cell factor. In: Stem Cells. 1994 ; Vol. 12, No. 5. pp. 521-526.
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AU - Brizzi, M. F.

AU - Camaschella, C.

AU - Pietsch, T.

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