Human platelet clumping by bovine fibrinogen

Research output: Contribution to journalArticle


Aggregation of human platelets after addition of bovine plasma or of purified bovine fibrinogen preparations from different sources is described. Some evidence for the hypothesis that bovine fibrinogen itself is the trigger of aggregation has been provided. The mechanism by which bovine fibrinogen clumps human platelets has been investigated: bovine fibrinogen could clump human platelets by a direct mechanism and also, independently of this immediate effect, release endogenous ADP which would induce further platelet aggregation.

Original languageEnglish
Pages (from-to)21-26
Number of pages6
JournalActa Universitatis Carolinae Medica
Volumemono 53-54
Publication statusPublished - 1972

ASJC Scopus subject areas

  • Medicine(all)

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