Human polyomavirus BK

Potential role in cancer

D. Fioriti, M. Videtta, M. Mischitelli, A. M. Degener, G. Russo, A. Giordano, V. Pietropaolo

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

In human cancer, a role has been suggested for the human polyomavirus BK, primarily associated with tubulointerstitial nephritis and ureteric stenosis in renal transplant recipients, and with hemorrhagic cystitis in bone marrow transplant (BMT) recipients. After the initial infection, primarily unapparent and without clinical signs, the virus disseminates and establishes a persistent infection in the urinary tract and lymphocytes. There is correlative evidence regarding potential role of polyomavirus BK in cancer. In fact, the BK virus (BKV) DNA (complete genome and/or subgenomic fragments containing the early region) is able to transform embryonic fibroblasts and cells cultured from kidney and brain of hamster, mouse, rat, rabbit, and monkey. Nevertheless, transformation of human cells by BKV is inefficient and often abortive. Evidence supporting a possible role for BKV in human cancer has accumulated slowly in recent years, after the advent of polymerase chain reaction (PCR). BKV is known to commonly establish persistent infections in people and to be excreted in the urine by individuals who are asymptomatic, complicating the evaluation of its potential role in development of human cancer. Therefore, there is no certain proof that human polyomavirus BK directly causes the cancer in humans or acts as a cofactor in the pathogenesis of some types of human cancer.

Original languageEnglish
Pages (from-to)402-406
Number of pages5
JournalJournal of Cellular Physiology
Volume204
Issue number2
DOIs
Publication statusPublished - Aug 2005

Fingerprint

BK Virus
Viruses
Transplants
Neoplasms
Lymphocytes
Polymerase chain reaction
Fibroblasts
Kidney
Interstitial Nephritis
Rats
Cystitis
Brain
Bone
Human Development
Genes
Cells
Infection
Urinary Tract Infections
Cricetinae
Haplorhini

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Cell Biology
  • Physiology

Cite this

Fioriti, D., Videtta, M., Mischitelli, M., Degener, A. M., Russo, G., Giordano, A., & Pietropaolo, V. (2005). Human polyomavirus BK: Potential role in cancer. Journal of Cellular Physiology, 204(2), 402-406. https://doi.org/10.1002/jcp.20300

Human polyomavirus BK : Potential role in cancer. / Fioriti, D.; Videtta, M.; Mischitelli, M.; Degener, A. M.; Russo, G.; Giordano, A.; Pietropaolo, V.

In: Journal of Cellular Physiology, Vol. 204, No. 2, 08.2005, p. 402-406.

Research output: Contribution to journalArticle

Fioriti, D, Videtta, M, Mischitelli, M, Degener, AM, Russo, G, Giordano, A & Pietropaolo, V 2005, 'Human polyomavirus BK: Potential role in cancer', Journal of Cellular Physiology, vol. 204, no. 2, pp. 402-406. https://doi.org/10.1002/jcp.20300
Fioriti D, Videtta M, Mischitelli M, Degener AM, Russo G, Giordano A et al. Human polyomavirus BK: Potential role in cancer. Journal of Cellular Physiology. 2005 Aug;204(2):402-406. https://doi.org/10.1002/jcp.20300
Fioriti, D. ; Videtta, M. ; Mischitelli, M. ; Degener, A. M. ; Russo, G. ; Giordano, A. ; Pietropaolo, V. / Human polyomavirus BK : Potential role in cancer. In: Journal of Cellular Physiology. 2005 ; Vol. 204, No. 2. pp. 402-406.
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