Human prion protein helices: Studying their stability by molecular dynamics simulations

Susan Costantini, Angelo M. Facchiano

Research output: Contribution to journalArticlepeer-review

Abstract

To study the intrinsic structural properties of three human prion helices and analyse their stability, we conducted olecular dynamics simulations, applied helix propensity predictions and evaluated the energetic contribution of he helical regions to the PrP protein stability. Our results suggest that three helices present different stability and the helix results the least stable.

Original languageEnglish
Pages (from-to)1057-1062
Number of pages6
JournalProtein and Peptide Letters
Volume16
Issue number9
DOIs
Publication statusPublished - Sep 2009

Keywords

  • Helical peptides
  • Helix propensity
  • Helix stability
  • Molecular dynamics
  • Prion

ASJC Scopus subject areas

  • Biochemistry
  • Structural Biology

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