Human prostacyclin platelet receptors and platelet lipid composition

P. A. Modesti, R. Abbate, D. Prisco, G. F. Gensini

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Abstract

To assess the role of the cellular lipid environment in the expression of prostacyclin (PGI2) membrane receptors, PGI2, binding sites together with cholesterol and phospholipid content in platelets from 17 healthy subjects were investigated. Membrane receptors were investigated by a direct radioligand binding method using [3H]PGI2 as radiolabeled ligand. Significant negative correlations between PGI2 high-affinity receptors and platelet cholesterol content (r =-0.787, p <0.001) and platelet cholesterol/phospholipid ratio (r = -0.946, P <0.001) were observed; on the contrary phospholipid content was positively correlated with the number of high-affinity receptors (r = 0.610, P <0.01). These results indicate that physiological changes in platelet lipid composition can affect membrane receptor number.

Original languageEnglish
Pages (from-to)309-315
Number of pages7
JournalJournal of Lipid Mediators
Volume2
Issue number6
Publication statusPublished - 1990

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ASJC Scopus subject areas

  • Immunology
  • Pharmacology

Cite this

Modesti, P. A., Abbate, R., Prisco, D., & Gensini, G. F. (1990). Human prostacyclin platelet receptors and platelet lipid composition. Journal of Lipid Mediators, 2(6), 309-315.