Human prostacyclin platelet receptors and platelet lipid composition

P. A. Modesti, R. Abbate, D. Prisco, G. F. Gensini

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

To assess the role of the cellular lipid environment in the expression of prostacyclin (PGI2) membrane receptors, PGI2, binding sites together with cholesterol and phospholipid content in platelets from 17 healthy subjects were investigated. Membrane receptors were investigated by a direct radioligand binding method using [3H]PGI2 as radiolabeled ligand. Significant negative correlations between PGI2 high-affinity receptors and platelet cholesterol content (r =-0.787, p <0.001) and platelet cholesterol/phospholipid ratio (r = -0.946, P <0.001) were observed; on the contrary phospholipid content was positively correlated with the number of high-affinity receptors (r = 0.610, P <0.01). These results indicate that physiological changes in platelet lipid composition can affect membrane receptor number.

Original languageEnglish
Pages (from-to)309-315
Number of pages7
JournalJournal of Lipid Mediators
Volume2
Issue number6
Publication statusPublished - 1990

Fingerprint

Epoprostenol
Blood Platelets
Lipids
Phospholipids
Cholesterol
Membranes
Epoprostenol Receptors
Healthy Volunteers
Binding Sites
Ligands
human PTGIR protein

ASJC Scopus subject areas

  • Immunology
  • Pharmacology

Cite this

Modesti, P. A., Abbate, R., Prisco, D., & Gensini, G. F. (1990). Human prostacyclin platelet receptors and platelet lipid composition. Journal of Lipid Mediators, 2(6), 309-315.

Human prostacyclin platelet receptors and platelet lipid composition. / Modesti, P. A.; Abbate, R.; Prisco, D.; Gensini, G. F.

In: Journal of Lipid Mediators, Vol. 2, No. 6, 1990, p. 309-315.

Research output: Contribution to journalArticle

Modesti, PA, Abbate, R, Prisco, D & Gensini, GF 1990, 'Human prostacyclin platelet receptors and platelet lipid composition', Journal of Lipid Mediators, vol. 2, no. 6, pp. 309-315.
Modesti PA, Abbate R, Prisco D, Gensini GF. Human prostacyclin platelet receptors and platelet lipid composition. Journal of Lipid Mediators. 1990;2(6):309-315.
Modesti, P. A. ; Abbate, R. ; Prisco, D. ; Gensini, G. F. / Human prostacyclin platelet receptors and platelet lipid composition. In: Journal of Lipid Mediators. 1990 ; Vol. 2, No. 6. pp. 309-315.
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