Human protein C concentrate in a patient with meningitis and bleeding as a complication of treatment with recombinant activated protein C

Sergio Colombo, Martina Crivellari, Milena Mucci, Valentina Plumari, Paolo Silvani, Patrizia Della Valle, Armando D'Angelo, Alberto Zangrillo

Research output: Contribution to journalArticlepeer-review

Abstract

Some case reports suggest that protein C zymogen supplementation may improve the outcome of patients with congenital or acquired protein C deficiency, such as sepsis-induced purpura fulminans. We describe the case report of a patient suffering from meningitis who developed a bleeding complication after recombinant human activated protein C administration and was successfully treated without any further bleeding complication with protein C concentrate. Protein C concentrate can be considered in adult patients with meningitis, even if at risk or in the presence of bleeding.

Original languageEnglish
Pages (from-to)62-64
Number of pages3
JournalSigna Vitae
Volume8
Issue number1
Publication statusPublished - 2013

Keywords

  • Bleeding
  • Protein C
  • Purpura fulmi-nans
  • Sepsis

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine
  • Emergency Medicine

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