Human protein C concentrates in adult septic patients

Giovanni Landoni; Martina Crivellari; Giacomo Monti; Chiara Gerli; Paolo Silvani; Alberto Zangrillo

Human protein C concentrates in adult septic patients

Giovanni Landoni, Martina Crivellari, Giacomo Monti, Chiara Gerli, Paolo Silvani, Alberto Zangrillo

IRCCS Ospedale San Raffaele

Research output: Contribution to journal › Article › peer-review

Abstract

Some case reports and case series suggest that protein C concentrates may improve the outcome in patients with congenital or acquired protein C deficiency (not only in those with sepsis induced purpura fulminans). We reviewed the published literature on the use of protein C concentrates in adult septic patients and found that it is limited to less than 70 patients reported in observational studies with a 70% survival, and added our personal experience (two adult patients with sepsis and contraindications to recombinant activated protein C).

Original language	English
Pages (from-to)	13-17
Number of pages	5
Journal	Signa Vitae
Volume	3
Issue number	2
Publication status	Published - 2008

Keywords

Cardiac surgery
Protein C
Sepsis

ASJC Scopus subject areas

Critical Care and Intensive Care Medicine
Emergency Medicine

Cite this

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abstract = "Some case reports and case series suggest that protein C concentrates may improve the outcome in patients with congenital or acquired protein C deficiency (not only in those with sepsis induced purpura fulminans). We reviewed the published literature on the use of protein C concentrates in adult septic patients and found that it is limited to less than 70 patients reported in observational studies with a 70% survival, and added our personal experience (two adult patients with sepsis and contraindications to recombinant activated protein C).",

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AU - Landoni, Giovanni

AU - Crivellari, Martina

AU - Monti, Giacomo

AU - Gerli, Chiara

AU - Silvani, Paolo

AU - Zangrillo, Alberto

PY - 2008

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AB - Some case reports and case series suggest that protein C concentrates may improve the outcome in patients with congenital or acquired protein C deficiency (not only in those with sepsis induced purpura fulminans). We reviewed the published literature on the use of protein C concentrates in adult septic patients and found that it is limited to less than 70 patients reported in observational studies with a 70% survival, and added our personal experience (two adult patients with sepsis and contraindications to recombinant activated protein C).

KW - Cardiac surgery

KW - Protein C

KW - Sepsis

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Human protein C concentrates in adult septic patients

Abstract

Keywords

ASJC Scopus subject areas

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