Human protein C concentrates in adult septic patients

Giovanni Landoni, Martina Crivellari, Giacomo Monti, Chiara Gerli, Paolo Silvani, Alberto Zangrillo

Research output: Contribution to journalArticlepeer-review


Some case reports and case series suggest that protein C concentrates may improve the outcome in patients with congenital or acquired protein C deficiency (not only in those with sepsis induced purpura fulminans). We reviewed the published literature on the use of protein C concentrates in adult septic patients and found that it is limited to less than 70 patients reported in observational studies with a 70% survival, and added our personal experience (two adult patients with sepsis and contraindications to recombinant activated protein C).

Original languageEnglish
Pages (from-to)13-17
Number of pages5
JournalSigna Vitae
Issue number2
Publication statusPublished - 2008


  • Cardiac surgery
  • Protein C
  • Sepsis

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine
  • Emergency Medicine


Dive into the research topics of 'Human protein C concentrates in adult septic patients'. Together they form a unique fingerprint.

Cite this