In vivo suppression of neovascularization by in situ administration of human recombinant interferon α2a (hrIFN-α2a) was tested on the chick embryo area vasculosa (AV). Methylcellulose discs, each containing 5 IU of hrlFN-α2a were implanted onto the AV at Hamburger-Hamilton (HH) stage 13, and inhibition of blood vessel growth was morphometrically evaluated between HH stages 20 and 27. Our results show: (i) a decreased extent of the AV; (ii) a decreased AV total vessel length; (iii) modified percent ratios of different classes of AV vessels having a definite length. The observed effects of treating with hrIFN-α2a are likely attributable to inhibition of endothelial cell proliferation.
|Number of pages||5|
|Journal||International journal of microcirculation, clinical and experimental / sponsored by the European Society for Microcirculation|
|Publication status||Published - Jul 1996|
- Area vasculosa
- Interferon α
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine