Human recombinant interferon alpha-2a inhibits angiogenesis of chick area vasculosa in shell-less culture

D. Ribatti, A. Vacca, Monica Iurlaro, R. Ria, Luisa Roncali, F. Dammacco

Research output: Contribution to journalArticlepeer-review

Abstract

In vivo suppression of neovascularization by in situ administration of human recombinant interferon α2a (hrIFN-α2a) was tested on the chick embryo area vasculosa (AV). Methylcellulose discs, each containing 5 IU of hrlFN-α2a were implanted onto the AV at Hamburger-Hamilton (HH) stage 13, and inhibition of blood vessel growth was morphometrically evaluated between HH stages 20 and 27. Our results show: (i) a decreased extent of the AV; (ii) a decreased AV total vessel length; (iii) modified percent ratios of different classes of AV vessels having a definite length. The observed effects of treating with hrIFN-α2a are likely attributable to inhibition of endothelial cell proliferation.

Original languageEnglish
Pages (from-to)165-169
Number of pages5
JournalInternational journal of microcirculation, clinical and experimental / sponsored by the European Society for Microcirculation
Volume16
Issue number4
Publication statusPublished - Jul 1996

Keywords

  • Anti-angiogenesis
  • Area vasculosa
  • Interferon α

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology

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