Human renal cancer stem cells

Benedetta Bussolati, Benjamin Dekel, Bruno Azzarone, Giovanni Camussi

Research output: Contribution to journalArticlepeer-review

Abstract

Cancer stem cells (CSCs), isolated in renal carcinomas, exhibit tumor-initiating capabilities and pluripotency. No specific CSC markers have been identified so far; therefore, their characterization is mainly based on functional studies. As they are resistant to chemo and radio therapy, renal CSCs may have a relevant role in tumor establishment, progression, and recurrence. CSCs were also shown to contribute to intra-tumor vasculogenesis through an endothelial differentiation and to favor the generation of the pre-metastatic niche through the release of exosomes/microvesicles.

Original languageEnglish
Pages (from-to)141-146
Number of pages6
JournalCancer Letters
Volume338
Issue number1
DOIs
Publication statusPublished - Sep 10 2013

Keywords

  • Angiogenesis
  • Differentiation therapy
  • Renal cell carcinoma
  • Tumor stem cells
  • Wilms' tumor

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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