Human T- and B-cell functions in SCID-hu mice

Maria Grazia Roncarolo, José M. Carballido, Matthieu Rouleau, Reiko Namikawa, Jan E. De Vries

Research output: Contribution to journalArticle

Abstract

SCID mice transplanted with human fetal liver and thymus (SCID-hu Thy/Liv) provide a unique in-vivo model to study human T-cell development and clonal selection mechanisms. This SCID-hu mouse model can be adapted to study the role of thymic epithelial cells, or bone marrow-derived cells in transplantation tolerance. In addition, these mice have circulating human T cells, which mediate human allograft rejection in vivo. SCID-hu mice constructed with fetal bones and thymus (SCID-hu BM/Thy) have both circulating human T and B cells, and can be used to study human B-cell development and B-cell functions. In addition, human T-B-cell interactions resulting in human lg production and the modulating effects of cytokines and cytokine receptor antagonists on this process, can be monitored. Collectively, this information indicates that the SCID-hu mouse is a powerful and versatile model to study human immune responses in vivo.

Original languageEnglish
Pages (from-to)207-213
Number of pages7
JournalSeminars in Immunology
Volume8
Issue number4
DOIs
Publication statusPublished - Aug 1996

Keywords

  • Human organ
  • Human T- and B-cell development
  • Regulation of Ig synthesis
  • SCID-hu mice
  • T-cell tolerance

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Infectious Diseases

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  • Cite this

    Roncarolo, M. G., Carballido, J. M., Rouleau, M., Namikawa, R., & De Vries, J. E. (1996). Human T- and B-cell functions in SCID-hu mice. Seminars in Immunology, 8(4), 207-213. https://doi.org/10.1006/smim.1996.0026