Human T-cell leukemia/lymphoma virus type 1 nonstructural genes and their functions

Christophe Nicot, Robert L. Harrod, Vincenzo Ciminale, Genoveffa Franchini

Research output: Contribution to journalArticle

Abstract

The human T-cell leukemia/lymphoma virus (HTLV) genome, in addition to the structural Gag and Env proteins and retroviral enzymes, carries a region at its 3′ end originally designated pX. To date, we know that this region encodes two essential transcriptional and post-transcriptional positive regulators of viral expression, the Tax and Rex proteins, respectively (reviewed elsewhere in this issue). Here, we will review current knowledge of the functions of three additional proteins encoded in the pX region, p12I, p13II, and p30II.

Original languageEnglish
Pages (from-to)6026-6034
Number of pages9
JournalOncogene
Volume24
Issue number39
DOIs
Publication statusPublished - Sep 5 2005

Keywords

  • Genes
  • HTLV-1
  • Proteins
  • Retrovirus

ASJC Scopus subject areas

  • Molecular Biology
  • Cancer Research
  • Genetics

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