Human T cell receptor for IgM: specificity for the pentameric Fc fragment

M. Ferrarini, L. Moretta, M. C. Mingari, P. Tonda, B. Pernis

Research output: Contribution to journalArticlepeer-review

Abstract

The specificity of the IgM expressed by human T cells cultured in IgM free media was investigated. IgM receptors were detected using a rosette system with ox erythrocytes coated with rabbit antibody (EA(IgM)), and the inhibitory capacity of different IgM fragments in the rosette system was tested. It was found that F(c) 5μ but not F(ab') 2μ, nor monomeric IgM (8 S IgM) inhibited EA(IgM) rosette forming cells. This indicates that the receptor present on the surface of T cells has affinity for a structure located in the Fc portion of the pentameric IgM.

Original languageEnglish
Pages (from-to)520-521
Number of pages2
JournalEuropean Journal of Immunology
Volume6
Issue number7
Publication statusPublished - 1976

ASJC Scopus subject areas

  • Immunology

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