Human T cells in cord blood: Abnormalities in Ia antigens induction by phytohemagglutinin and in autologous mixed lymphocyte reactions

M. Scudeletti, F. Torrielli, D. Pende, C. Piccardo, F. Indiveri, S. Ferrone

Research output: Contribution to journalArticlepeer-review

Abstract

About 25% of human T cells isolated from cord blood acquired Ia antigens following stimulation with phytohemagglutinin (PHA) for 72 hr. This percentage is markedly lower than that found in PHA-activated T-cell populations (PHA-T cells) isolated from peripheral blood of adults. The low expression of Ia antigens by human T cells from cord blood does not reflect abnormalities in the sensitivity to PHA stimulation and/or in the kinetics of induction of Ia antigens. PHA-T cells from cord blood display a low stimulatory activity in autologous mixed lymphocyte reactions (MLR). The defect does not reflect a nonspecific abnormality in the stimulatory activity of PHA-T cells from cord blood, since the latter do not differ from PHA-T cells from adults in their ability to stimulate allogeneic T cells from adults. Furthermore the defect does not reflect a nonspecific abnormality in the proliferative response of T cells from cord blood, since the latter display a normal proliferative response to PHA-T cells from adults. The defect in the proliferative response is not restricted to the autologous MLR with PHA-T cells, since it was found also in autologous MLR with non-T cells as stimulators. Correlation of the temporal evolution of the abnormalities of human T cells with the maturation of the immune system may contribute to our understanding of the role of Ia antigens in cell-cell interactions and of the biological significance of abnormalities of autologous MLR.

Original languageEnglish
Pages (from-to)521-530
Number of pages10
JournalCellular Immunology
Volume88
Issue number2
DOIs
Publication statusPublished - Oct 15 1984

ASJC Scopus subject areas

  • Cell Biology
  • Immunology

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