Human T-lymphocyte subpopulations: Alterations in systemic lupus erythematosus

A. Moretta, M. C. Mingari, D. Santoli, P. Perlmann, L. Moretta

Research output: Contribution to journalArticlepeer-review

Abstract

Sharply reduced proportions of T cells with Fc receptors for IgG (TG cells) were observed in blood samples from patients with systemic lupus erythematosus (SLE), mainly with active disease. This T-cell subset has previously been shown to be a suppressor in the pokeweed mitogen (PWM)-dependent B-cell differentiation. In contrast, the percentages of T cells with Fc receptors for IgM (TM cells), which have been shown to help immunoglobulin production, were not different from those of normals. TG cells present in the circulation of SLE patients were analyzed for their functional capacities in antibody-dependent cell-mediated cytoxicity and in the suppression of a PWM-induced B-cell differentiation. In both these assays TG cells from SLE patients had normal effector cell activity. This suggests that the T-cell defects present in SLE patients are mainly of a quantitative rather than a qualitative type.

Original languageEnglish
Pages (from-to)223-228
Number of pages6
JournalScandinavian Journal of Immunology
Volume10
Issue number3
Publication statusPublished - 1979

ASJC Scopus subject areas

  • Immunology

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