TY - JOUR
T1 - Human TCRγδ
+ T cells represent a novel target for IL-27 activity
AU - Morandi, Fabio
AU - Prigione, Ignazia
AU - Airoldi, Irma
PY - 2012/6
Y1 - 2012/6
N2 - IL-27 and TCRγδ
+ T lymphocytes play critical roles in both innate and adaptive immune responses in health and disease, including infection and tumors. Although the activity of IL-27 is well characterized in different human immune cells, no information is available on the role of IL-27 in human TCRγδ
+ T lymphocytes. Here, we provide the first evidence that TCRγδ
+ T lymphocytes express both gp130 and WSX-1 chains of IL-27R, and that IL-27 may function in TCRγδ
+ T cells by (i) inducing STAT1 and STAT3 phosphorylation, (ii) stimulating cytotoxicity against tumor cells through upregulation of cytotoxic granules production, (iii) reducing the release of Th2-related cytokines, such as IL-5 and IL-13, and inducing IFN-γ production, and (iv) upregulating the expression of CD62L. These results highlighted a novel immunoregulatory property of human IL-27 that may be relevant in the immune response against tumors. Our results may offer new perspectives for the development of future clinical trials using IL-27 and TCRγδ
+ cells for cancer immunotherapy.
AB - IL-27 and TCRγδ
+ T lymphocytes play critical roles in both innate and adaptive immune responses in health and disease, including infection and tumors. Although the activity of IL-27 is well characterized in different human immune cells, no information is available on the role of IL-27 in human TCRγδ
+ T lymphocytes. Here, we provide the first evidence that TCRγδ
+ T lymphocytes express both gp130 and WSX-1 chains of IL-27R, and that IL-27 may function in TCRγδ
+ T cells by (i) inducing STAT1 and STAT3 phosphorylation, (ii) stimulating cytotoxicity against tumor cells through upregulation of cytotoxic granules production, (iii) reducing the release of Th2-related cytokines, such as IL-5 and IL-13, and inducing IFN-γ production, and (iv) upregulating the expression of CD62L. These results highlighted a novel immunoregulatory property of human IL-27 that may be relevant in the immune response against tumors. Our results may offer new perspectives for the development of future clinical trials using IL-27 and TCRγδ
+ cells for cancer immunotherapy.
KW - γδ T cells
KW - Cytokine receptors
KW - Cytokines
KW - Human
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UR - http://www.scopus.com/inward/citedby.url?scp=84862117127&partnerID=8YFLogxK
U2 - 10.1002/eji.201142241
DO - 10.1002/eji.201142241
M3 - Article
C2 - 22678908
AN - SCOPUS:84862117127
VL - 42
SP - 1547
EP - 1552
JO - European Journal of Immunology
JF - European Journal of Immunology
SN - 0014-2980
IS - 6
ER -