Human Thy-1 antigen: Cell surface expression on early T and B lymphocytes

M. A. Ritter, C. A. suavage, D. Delia

Research output: Contribution to journalArticle

Abstract

Human Thy-1 is present on the surface of only a small proportion of haemopoietic cells (thymus - 0.2 - 10%; bone marrow - 0.1 - 0.5%). We have analysed these Thy-1+ cells in more detail using immunofluorescence on a wide range of human haemopoietic cells lines and fresh leukaemic blasts; both situations where rare cells can become clonally expanded. The data demonstrate that Thy-1 is confined to the early stages of T- and B-lymphocyte development, and is absent from all myeloid cells. The Thy-1+ B cells represent late pre-B (cμ+)/early sIgM+ B cells. The Thy-1+ T cells are situated in the outer thymic cortex. Dual immunofluorescence analysis of FACS separated Thy-1+ thymocytes shows them to have the antigenic phenotype and morphology of prothymocytes/early thymocytes (some overlap seen with CALLA, TdT, OKT6 and OKT1).

Original languageEnglish
Pages (from-to)555-564
Number of pages10
JournalImmunology
Volume49
Issue number3
Publication statusPublished - 1983

ASJC Scopus subject areas

  • Immunology

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    Ritter, M. A., suavage, C. A., & Delia, D. (1983). Human Thy-1 antigen: Cell surface expression on early T and B lymphocytes. Immunology, 49(3), 555-564.