Human tolerogenic DC-10: Perspectives for clinical applications

Giada Amodio, Silvia Gregori

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

Dendritic cells (DCs) are critically involved in inducing either immunity or tolerance. During the last decades efforts have been devoted to the development of ad hoc methods to manipulate DCs in vitro to enhance or stabilize their tolerogenic properties. Addition of IL-10 during monocyte-derived DC differentiation allows the induction of DC-10, a subset of human tolerogenic DCs characterized by high IL-10/IL-12 ratio and co-expression of high levels of the tolerogenic molecules HLA-G and immunoglobulin-like transcript 4. DC-10 are potent inducers of adaptive type 1 regulatory T cells, well known to promote and maintain peripheral tolerance. In this review we provide an in-depth comparison of the phenotype and mechanisms of suppression mediated by DC-10 and other known regulatory antigen-presenting cells currently under clinical development. We discuss the clinical therapeutic application of DC-10 as inducers of type 1 regulatory T cells for tailoring regulatory T-cell-based cell therapy, and the use of DC-10 as adoptive cell therapy for promoting and restoring tolerance in T-cell-mediated diseases.

Original languageEnglish
Article number14
JournalTransplantation Research
Volume1
Issue number1
DOIs
Publication statusPublished - Sep 28 2012

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Dendritic Cells
Regulatory T-Lymphocytes
Cell- and Tissue-Based Therapy
Interleukin-10
HLA-G Antigens
Peripheral Tolerance
Antigen-Presenting Cells
Interleukin-12
Immunoglobulins
Monocytes
Cell Differentiation
Immunity
T-Lymphocytes
Phenotype

Keywords

  • Dendritic cells
  • IL-10
  • Regulatory antigen-presenting cells
  • Tolerance
  • Type 1 regulatory T cells

ASJC Scopus subject areas

  • Transplantation
  • Immunology

Cite this

Human tolerogenic DC-10 : Perspectives for clinical applications. / Amodio, Giada; Gregori, Silvia.

In: Transplantation Research, Vol. 1, No. 1, 14, 28.09.2012.

Research output: Contribution to journalArticle

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