Human TRK proto-oncogene maps to chromosome 1q32-q41

M. Miozzo, M. A. Pierotti, G. Sozzi, P. Radice, I. Bongarzone, N. K. Spurr, G. Della Porta

Research output: Contribution to journalArticlepeer-review

Abstract

The chromosomal localization of TRK, a gene coding for a putative receptor molecule with an associated tyrosine kinase activity that we have found activated in 25% of patients with papillary thyroid carcinoma, was determined by Southern blot analysis of a panel of human-rodent somatic cells using a cDNA clone containing the entire human TRK proto-oncogene (Martin-Zanca et al., 1986). The TRK gene was assigned to chromosome 1. One hybrid that had retained only the short arm of the human chromosome 1 was negative. Subsequently, in situ hybridization of the same probe to human metaphase chromosomes localized the TRK gene to 1q32-q41.

Original languageEnglish
Pages (from-to)1411-1414
Number of pages4
JournalOncogene
Volume5
Issue number9
Publication statusPublished - 1990

ASJC Scopus subject areas

  • Cancer Research
  • Genetics
  • Molecular Biology

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