Abstract
Humoral and cellular immune responses to Salmonella typhi have been studied in nine children with typhoid fever. By using dot immunobinding assay, anti-O-polysaccharide chain and antilipid A antibody titers have been evaluated during the course of the disease. Anti-O-polysaccharide chain antibody titers are lower at the first week and increase up to the third week of the infection. On the other hand, antilipid A antibody levels, which are already higher at the beginning of the disease, progressively augment during the following weeks. Concerning cellular immunity to S. typhi, antibacterial activity mediated by typhoid peripheral mononuclear cells has been determined. Results show this function to be depressed in the initial phase of typhoid, increasing with the time. Together, these data bring new insight on immunity in typhoid patients.
| Original language | English |
|---|---|
| Pages (from-to) | 191-195 |
| Number of pages | 5 |
| Journal | Journal of Clinical Laboratory Analysis |
| Volume | 3 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 1989 |
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ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
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Humoral and cellular immune responses to Salmonella typhi in patients with typhoid fever. / Mastroianni, C. M.; Jirillo, E.; De Simone, C.; Grassi, P. P.; Maffione, A. B.; Catino, A. M.; Vullo, V.; Misefari, A.; Delia, S.
In: Journal of Clinical Laboratory Analysis, Vol. 3, No. 3, 1989, p. 191-195.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Humoral and cellular immune responses to Salmonella typhi in patients with typhoid fever
AU - Mastroianni, C. M.
AU - Jirillo, E.
AU - De Simone, C.
AU - Grassi, P. P.
AU - Maffione, A. B.
AU - Catino, A. M.
AU - Vullo, V.
AU - Misefari, A.
AU - Delia, S.
PY - 1989
Y1 - 1989
N2 - Humoral and cellular immune responses to Salmonella typhi have been studied in nine children with typhoid fever. By using dot immunobinding assay, anti-O-polysaccharide chain and antilipid A antibody titers have been evaluated during the course of the disease. Anti-O-polysaccharide chain antibody titers are lower at the first week and increase up to the third week of the infection. On the other hand, antilipid A antibody levels, which are already higher at the beginning of the disease, progressively augment during the following weeks. Concerning cellular immunity to S. typhi, antibacterial activity mediated by typhoid peripheral mononuclear cells has been determined. Results show this function to be depressed in the initial phase of typhoid, increasing with the time. Together, these data bring new insight on immunity in typhoid patients.
AB - Humoral and cellular immune responses to Salmonella typhi have been studied in nine children with typhoid fever. By using dot immunobinding assay, anti-O-polysaccharide chain and antilipid A antibody titers have been evaluated during the course of the disease. Anti-O-polysaccharide chain antibody titers are lower at the first week and increase up to the third week of the infection. On the other hand, antilipid A antibody levels, which are already higher at the beginning of the disease, progressively augment during the following weeks. Concerning cellular immunity to S. typhi, antibacterial activity mediated by typhoid peripheral mononuclear cells has been determined. Results show this function to be depressed in the initial phase of typhoid, increasing with the time. Together, these data bring new insight on immunity in typhoid patients.
UR - http://www.scopus.com/inward/record.url?scp=0024952609&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0024952609&partnerID=8YFLogxK
U2 - 10.1002/jcla.1860030310
DO - 10.1002/jcla.1860030310
M3 - Article
C2 - 2754534
AN - SCOPUS:0024952609
VL - 3
SP - 191
EP - 195
JO - Journal of Clinical Laboratory Analysis
JF - Journal of Clinical Laboratory Analysis
SN - 0887-8013
IS - 3
ER -