Humoral and cellular immune responses to Salmonella typhi in patients with typhoid fever

C. M. Mastroianni, E. Jirillo, C. De Simone, P. P. Grassi, A. B. Maffione, A. M. Catino, V. Vullo, A. Misefari, S. Delia

Research output: Contribution to journalArticlepeer-review

Abstract

Humoral and cellular immune responses to Salmonella typhi have been studied in nine children with typhoid fever. By using dot immunobinding assay, anti-O-polysaccharide chain and antilipid A antibody titers have been evaluated during the course of the disease. Anti-O-polysaccharide chain antibody titers are lower at the first week and increase up to the third week of the infection. On the other hand, antilipid A antibody levels, which are already higher at the beginning of the disease, progressively augment during the following weeks. Concerning cellular immunity to S. typhi, antibacterial activity mediated by typhoid peripheral mononuclear cells has been determined. Results show this function to be depressed in the initial phase of typhoid, increasing with the time. Together, these data bring new insight on immunity in typhoid patients.

Original languageEnglish
Pages (from-to)191-195
Number of pages5
JournalJournal of Clinical Laboratory Analysis
Volume3
Issue number3
DOIs
Publication statusPublished - 1989

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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