Humoral autoimmune responses to glutamic acid decarboxylase have similar target epitopes and subclass that show titer-dependent disease association

Sandra Piquer, Cristina Belloni, Vito Lampasona, Elena Bazzigaluppi, Marika Vianello, Bruno Giometto, Emanuele Bosi, Gian Franco Bottazzo, Ezio Bonifacio

Research output: Contribution to journalArticlepeer-review

Abstract

Glutamic acid decarboxylase (GAD) is an autoantigen in stiff man syndrome (SMS) and type 1 diabetes (T1DM). Different GAD autoantibody characteristics in these disorders have suggested distinct underlying mechanisms of autoimmunity. Here, it is shown that increased prevalence of autoantibodies to GAD65 amino terminal and GAD67 epitopes and autoantibodies of IgG2, IgG3, or IgG4 subclass in patients with SMS (P <0.001 vs. T1DM) are secondary to the markedly higher autoantibody titers in SMS patients (P <0.0001) and that autoantibody epitopes and subclasses were similar when patients were matched for autoantibody titer. Exposure to autoantigen in the disorders is likely to involve similar humoral antigenic determinants, but different B cell regulation.

Original languageEnglish
Pages (from-to)31-35
Number of pages5
JournalClinical Immunology
Volume117
Issue number1
DOIs
Publication statusPublished - Oct 2005

Keywords

  • GAD antibodies
  • GAD epitopes
  • IgG subclasses
  • Stiff man syndrome
  • Type I diabetes

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

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