Humoral immune response against hepatitis C virus

Roberto Burioni, N. Mancini, F. Canducci, S. Carletti, A. Grieco, M. Perotti, G. Serafini, E. Berardinelli, S. Bighi, P. E. Varaldo, M. Clementi

Research output: Contribution to journalArticle


Antibodies are in several instances a reliable marker indicating vigorous immune response against infectious agents and in several viral diseases presence in the blood of specific anti-viral antibodies indicates an effective protection. However, this is not always true. For example, in the case of hepatitis C virus (HCV) an important human pathogen considered the causative agent of the nonA- nonB hepatitis, in spite of an intense antibody response there is no protection against a new infection and in the majority of infected individuals the virus overcomes host defences establishing a persistent infection. Here we describe how the dissection of the humoral immune response against HCV glycoprotein E2 of infected patients was useful for a better comprehension of the virus-host interplay. Cross-reactive antibodies directed against E2 are produced by the HCV-infected patient, but not all of them are protective, and some could even result to be detrimental for the patient. The cross-reactive anti-HCV/E2 humoral antibody response is complex and not necessarily completely beneficial to the host.

Original languageEnglish
Pages (from-to)125-127
Number of pages3
JournalJournal of Biological Regulators and Homeostatic Agents
Issue number2
Publication statusPublished - Apr 2003


  • Hepatitis C virus
  • Human monoclonal antibodies

ASJC Scopus subject areas

  • Immunology
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Physiology (medical)
  • Medicine (miscellaneous)
  • Physiology
  • Agricultural and Biological Sciences(all)

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    Burioni, R., Mancini, N., Canducci, F., Carletti, S., Grieco, A., Perotti, M., Serafini, G., Berardinelli, E., Bighi, S., Varaldo, P. E., & Clementi, M. (2003). Humoral immune response against hepatitis C virus. Journal of Biological Regulators and Homeostatic Agents, 17(2), 125-127.