Humoral immunotherapy of multiple myeloma: Perspectives and perplexities

Andrea Di Bernardo, Paolo MacOr, Carla Guarnotta, Giovanni Franco, Ada Maria Florena, Francesco Tedesco, Claudio Tripodo

Research output: Contribution to journalArticlepeer-review

Abstract

Importance of the field: Multiple myeloma (MM) is a hematological malignancy still remaining incurable despite the various therapies available, mainly because of the high fraction of refractory/relapsing cases. Therefore, the development of novel therapeutic approaches is urgently needed to overcome conventional treatment resistance. Areas covered in this review: In the era of targeted therapies, treatments combining a high specificity for neoplastic cells and the capability to interfere with environmental signals should be regarded as the weapons of choice. Monoclonal antibody (mAb)-based humoral immunotherapy could satisfy both these requirements when applied to MM. Indeed, many of the molecules expressed on MM cells, such as CD38, CD40, CD49d, CD138 and CD162 are involved in the adhesive dynamics regulating the crosstalk between MM and the BM-microenvironment. What the reader will gain: In this study we review those MM-associated molecules that have shown promising antitumor effects as targets of specific mAbs in preclinical settings, thus deserving to be considered for clinical investigation. Take home message: mAbs directed against MM-associated adhesion markers should be taken into account in clinical practice, since they could possibly represent the best available combination of tumor cytotoxicity, environmental signal deprivation and immune system redirection.

Original languageEnglish
Pages (from-to)863-873
Number of pages11
JournalExpert Opinion on Biological Therapy
Volume10
Issue number6
DOIs
Publication statusPublished - Jun 2010

Keywords

  • Immunotherapy
  • Molecular targets
  • Monoclonal antibodies
  • Multiple myeloma

ASJC Scopus subject areas

  • Pharmacology
  • Clinical Biochemistry
  • Drug Discovery

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