Humoral innate immunity at the crossroad between microbe and matrix recognition: The role of PTX3 in tissue damage

Andrea Doni, Giovanna D'Amico, Diego Morone, Alberto Mantovani, Cecilia Garlanda

Research output: Contribution to journalArticlepeer-review

Abstract

Innate immunity is involved in regulating inflammatory and tissue repair responses to injury. In particular, humoral innate immunity plays functions related to wound clearance from tissue debris, and regulation of macrophage and stromal cell activities. PTX3, a component of humoral innate immunity, orchestrates tissue repair by interacting with plasminogen and fibrin. Fluid-phase molecules of innate immunity interact with elements of the extracellular matrix, and some of the latter display opsonic activity against certain bacterial species.Thus, recognition of extracellular matrix and microbial components is a recurrent theme in the humoral arm of the innate immune system.

Original languageEnglish
JournalSeminars in Cell and Developmental Biology
DOIs
Publication statusAccepted/In press - Jul 15 2016

Keywords

  • Inflammation
  • Innate immunity
  • Pattern recognition molecule
  • Pentraxin-3 (PTX3)
  • Tissue repair

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

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