HuPho

The human phosphatase portal

Susanna Liberti, Francesca Sacco, Alberto Calderone, Livia Perfetto, Marta Iannuccelli, Simona Panni, Elena Santonico, Anita Palma, Aurelio P. Nardozza, Luisa Castagnoli, Gianni Cesareni

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Phosphatases and kinases contribute to the regulation of protein phosphorylation homeostasis in the cell. Phosphorylation is a key post-translational modification underlying the regulation of many cellular processes. Thus, a comprehensive picture of phosphatase function and the identification of their target substrates would aid a systematic approach to a mechanistic description of cell signalling. Here we present a website designed to facilitate the retrieval of information about human protein phosphatases. To this end we developed a search engine to recover and integrate information annotated in several publicly available web resources. In addition we present a text-mining-assisted annotation effort aimed at extracting phosphatase related data reported in the scientific literature. The HuPho (human phosphatases) website can be accessed at http://hupho.uniroma2.it.

Original languageEnglish
Pages (from-to)379-387
Number of pages9
JournalFEBS Journal
Volume280
Issue number2
DOIs
Publication statusPublished - Jan 2013

Fingerprint

Phosphoric Monoester Hydrolases
Phosphorylation
Websites
Cell signaling
Literature
Search Engine
Data Mining
Information Storage and Retrieval
Phosphoprotein Phosphatases
Post Translational Protein Processing
Search engines
Homeostasis
Phosphotransferases
Substrates
Proteins

Keywords

  • database
  • phosphatase substrates
  • phosphatases
  • phosphorylation
  • protein interaction

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology

Cite this

Liberti, S., Sacco, F., Calderone, A., Perfetto, L., Iannuccelli, M., Panni, S., ... Cesareni, G. (2013). HuPho: The human phosphatase portal. FEBS Journal, 280(2), 379-387. https://doi.org/10.1111/j.1742-4658.2012.08712.x

HuPho : The human phosphatase portal. / Liberti, Susanna; Sacco, Francesca; Calderone, Alberto; Perfetto, Livia; Iannuccelli, Marta; Panni, Simona; Santonico, Elena; Palma, Anita; Nardozza, Aurelio P.; Castagnoli, Luisa; Cesareni, Gianni.

In: FEBS Journal, Vol. 280, No. 2, 01.2013, p. 379-387.

Research output: Contribution to journalArticle

Liberti, S, Sacco, F, Calderone, A, Perfetto, L, Iannuccelli, M, Panni, S, Santonico, E, Palma, A, Nardozza, AP, Castagnoli, L & Cesareni, G 2013, 'HuPho: The human phosphatase portal', FEBS Journal, vol. 280, no. 2, pp. 379-387. https://doi.org/10.1111/j.1742-4658.2012.08712.x
Liberti S, Sacco F, Calderone A, Perfetto L, Iannuccelli M, Panni S et al. HuPho: The human phosphatase portal. FEBS Journal. 2013 Jan;280(2):379-387. https://doi.org/10.1111/j.1742-4658.2012.08712.x
Liberti, Susanna ; Sacco, Francesca ; Calderone, Alberto ; Perfetto, Livia ; Iannuccelli, Marta ; Panni, Simona ; Santonico, Elena ; Palma, Anita ; Nardozza, Aurelio P. ; Castagnoli, Luisa ; Cesareni, Gianni. / HuPho : The human phosphatase portal. In: FEBS Journal. 2013 ; Vol. 280, No. 2. pp. 379-387.
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