HuPho: The human phosphatase portal

Susanna Liberti, Francesca Sacco, Alberto Calderone, Livia Perfetto, Marta Iannuccelli, Simona Panni, Elena Santonico, Anita Palma, Aurelio P. Nardozza, Luisa Castagnoli, Gianni Cesareni

Research output: Contribution to journalArticlepeer-review

Abstract

Phosphatases and kinases contribute to the regulation of protein phosphorylation homeostasis in the cell. Phosphorylation is a key post-translational modification underlying the regulation of many cellular processes. Thus, a comprehensive picture of phosphatase function and the identification of their target substrates would aid a systematic approach to a mechanistic description of cell signalling. Here we present a website designed to facilitate the retrieval of information about human protein phosphatases. To this end we developed a search engine to recover and integrate information annotated in several publicly available web resources. In addition we present a text-mining-assisted annotation effort aimed at extracting phosphatase related data reported in the scientific literature. The HuPho (human phosphatases) website can be accessed at http://hupho.uniroma2.it.

Original languageEnglish
Pages (from-to)379-387
Number of pages9
JournalFEBS Journal
Volume280
Issue number2
DOIs
Publication statusPublished - Jan 2013

Keywords

  • database
  • phosphatase substrates
  • phosphatases
  • phosphorylation
  • protein interaction

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology

Fingerprint

Dive into the research topics of 'HuPho: The human phosphatase portal'. Together they form a unique fingerprint.

Cite this