Hutchinson-Gilford Progeria Syndrome and Severe Aortic Stenosis: A New Hope for Treatment

Francesco Musumeci, Antonio Giovanni Cammardella, Antonio Lio, Carmine Musto, Vincenzo Polizzi, Vitaliano Buffa, Andrea Montalto, Marina Comisso, Federico Ranocchi, Mauro Cassese

Research output: Contribution to journalArticlepeer-review

Abstract

Hutchinson-Gilford progeria syndrome is an autosomal dominant, rare, fatal pediatric segmental premature aging disease. Cardiovascular and cerebrovascular diseases constitute the major cause of morbidity and mortality. Patients with the syndrome and severe aortic valve stenosis have been described in the literature, and for all of them a strategy of conservative management has been followed. We describe the first successful treatment of a 23-year-old Hutchinson-Gilford progeria syndrome patient with severe aortic stenosis who underwent transapical transcatheter aortic valve replacement.

Original languageEnglish
Pages (from-to)e365-e367
JournalAnnals of Thoracic Surgery
Volume110
Issue number5
DOIs
Publication statusPublished - Nov 2020
Externally publishedYes

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine

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