TY - JOUR
T1 - Hyalinizing clear cell carcinoma of the parotid gland
T2 - Report of a recurrent case with aggressive cytomorphology and behavior diagnosed on fine-needle cytology sample
AU - Fulciniti, Franco
AU - Pia Curcio, Maria
AU - Liguori, Giuseppina
AU - Aquino, Gabriella
AU - Botti, Gerardo
AU - Campanile, Anna Cipolletta
AU - De Cecio, Rossella
AU - Pavone, Ettore
AU - Aversa, Corrado
AU - Perri, Francesco
AU - Caponigro, Francesco
AU - Ionna, Franco
PY - 2014/1
Y1 - 2014/1
N2 - A case of recurrent hyalinizing clear cell carcinoma (HCCC) of the parotid gland in a 46-year-old female is here introduced. The patient had undergone a left superficial parotidectomy 6 months ago in another institution for an alleged benign, circumscribed mass 2.4 cm in diameter of the left parotid gland. Histopathological examination revealed a poorly differentiated HCCC bearing a EWSR-1 translocation on FISH examination. Fine Needle Cytology (FNC) was performed on three separate soft tissue masses in the pre-masseterine area and a cytological diagnosis of recurrent, poorly differentiated, possibly aggressive variant of HCCC, was rendered. FISH performed on a destained Diff Quik stained smear demonstrated an ESWR-1 translocation, which supported the cytopathological diagnosis. The cytomorphologic features and the differential diagnosis of this aggressive variant of HCCC are briefly discussed.
AB - A case of recurrent hyalinizing clear cell carcinoma (HCCC) of the parotid gland in a 46-year-old female is here introduced. The patient had undergone a left superficial parotidectomy 6 months ago in another institution for an alleged benign, circumscribed mass 2.4 cm in diameter of the left parotid gland. Histopathological examination revealed a poorly differentiated HCCC bearing a EWSR-1 translocation on FISH examination. Fine Needle Cytology (FNC) was performed on three separate soft tissue masses in the pre-masseterine area and a cytological diagnosis of recurrent, poorly differentiated, possibly aggressive variant of HCCC, was rendered. FISH performed on a destained Diff Quik stained smear demonstrated an ESWR-1 translocation, which supported the cytopathological diagnosis. The cytomorphologic features and the differential diagnosis of this aggressive variant of HCCC are briefly discussed.
KW - aggressive tumors of salivary glands
KW - carcinoma of the parotid gland
KW - Fine needle cytology
KW - hyalinizing clear cell
KW - rare salivary gland tumors
KW - salivary gland tumors
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U2 - 10.1002/dc.22956
DO - 10.1002/dc.22956
M3 - Article
C2 - 23894005
AN - SCOPUS:84891469791
VL - 42
SP - 63
EP - 68
JO - Diagnostic Cytopathology
JF - Diagnostic Cytopathology
SN - 8755-1039
IS - 1
ER -