Hyalinizing clear cell carcinoma of the parotid gland: Report of a recurrent case with aggressive cytomorphology and behavior diagnosed on fine-needle cytology sample

Franco Fulciniti, Maria Pia Curcio, Giuseppina Liguori, Gabriella Aquino, Gerardo Botti, Anna Cipolletta Campanile, Rossella De Cecio, Ettore Pavone, Corrado Aversa, Francesco Perri, Francesco Caponigro, Franco Ionna

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A case of recurrent hyalinizing clear cell carcinoma (HCCC) of the parotid gland in a 46-year-old female is here introduced. The patient had undergone a left superficial parotidectomy 6 months ago in another institution for an alleged benign, circumscribed mass 2.4 cm in diameter of the left parotid gland. Histopathological examination revealed a poorly differentiated HCCC bearing a EWSR-1 translocation on FISH examination. Fine Needle Cytology (FNC) was performed on three separate soft tissue masses in the pre-masseterine area and a cytological diagnosis of recurrent, poorly differentiated, possibly aggressive variant of HCCC, was rendered. FISH performed on a destained Diff Quik stained smear demonstrated an ESWR-1 translocation, which supported the cytopathological diagnosis. The cytomorphologic features and the differential diagnosis of this aggressive variant of HCCC are briefly discussed.

Original languageEnglish
Pages (from-to)63-68
Number of pages6
JournalDiagnostic Cytopathology
Issue number1
Publication statusPublished - Jan 2014



  • aggressive tumors of salivary glands
  • carcinoma of the parotid gland
  • Fine needle cytology
  • hyalinizing clear cell
  • rare salivary gland tumors
  • salivary gland tumors

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology

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