Hyaluronic acid in the management of osteoarthritis: Injection therapies innovations

Valter Santilli, Marco Paoloni, Massimiliano Mangone, Federica Alviti, Andrea Bernetti

Research output: Contribution to journalArticlepeer-review


Osteoarthritis (OA) is a chronic degenerative joint disease characterized by pain and progressive functional limitation. Viscosupplementation with intra-articular (IA) hyaluronic acid (HA) could be a treatment option in OA, however recommendations made in different international guidelines for the non-surgical management of OA are not always concordant with regard to the role of IA injection therapies. Results from a recent Italian Consensus Conference underline how IA-HA to treat OA represents a widely used therapy in Italy. Specifically high molecular weight HA, crosslinked HA, and mobile reticulum HA are considered very useful to treat the OA joints from a great number of expert in Italy. These kinds of HA could reduce the NSAIDs intake, furthermore high-molecular weight and mobile reticulum HA are considered to be able to delay or avoid a joint prosthetic implant. This mini review highlights the results obtained from the Italian Consensus Conference "Appropriateness of clinical and organizational criteria for intra-articular injection therapies in osteoarthritis" and give further indication about innovation in IA-HA therapies.

Original languageEnglish
Pages (from-to)131-134
Number of pages4
JournalClinical Cases in Mineral and Bone Metabolism
Issue number2
Publication statusPublished - May 1 2016


  • Hyaluronic acid
  • Injections
  • Osteoarthritis

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism


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