Hyaluronic acid three-dimensional scaffold for surgical revision of retracting scars: A human experimental study

Angela Faga, Giovanni Nicoletti, Federica Brenta, Silvia Scevola, Giovanni Abatangelo, Paola Brun

Research output: Contribution to journalArticlepeer-review


An observational study was carried out at the Plastic and Reconstructive Surgery Unit of the University of Pavia - Salvatore Maugeri Research and Care Institute, Pavia, Italy, to assess the clinical and histological long-term outcomes of autologous skin grafting of fresh surgical wounds following previous repair with a hyaluronic acid three-dimensional scaffold (Hyalomatrix®). Eleven fresh wounds from surgical release of retracted scars were enrolled in this study. A stable skin-like tissue cover was observed in all of the treated wounds in an average 1 month's time; at the end of this study, after an average of 12 months' time, all of the reconstructed areas were pliable and stable, although an average retraction rate of 51·62% was showed. Histological observation and immunohistochemical analysis displayed integration of the graft within the surrounding tissues. A regenerated dermis with an extracellular matrix rich in type I collagen and elastic fibres and with reduced type III collagen rate was observed. The epidermis and dermoepidermal junction featured a normal appearance with well-structured dermal papillae, too. Although the histological features would suggest regeneration of a skin-like tissue, with a good dermis and no signs of scarring, the clinical problem of secondary contracture is still unsolved.

Original languageEnglish
Pages (from-to)329-335
Number of pages7
JournalInternational Wound Journal
Issue number3
Publication statusPublished - Jun 2013


  • Bioengineered tissue
  • Hyaluronic acid
  • Retraction
  • Scar
  • Skin regeneration

ASJC Scopus subject areas

  • Surgery
  • Dermatology


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