Hybrid core shell nanoparticles entrapping Gd-DTPA and 18F-FDG for simultaneous PET/MRI acquisitions

Donatella Vecchione, Marco Aiello, Carlo Cavaliere, Emanuele Nicolai, Paolo Antonio Netti, Enza Torino

Research output: Contribution to journalArticle

Abstract

Aim: Although there has been an improvement in the hardware and software of the PET/MRI system, the development of the nanoprobes exploiting the simultaneous acquisition of the bimodal data is still under investigation. Moreover, few studies on biocompatible and clinically relevant probes are available. This work presents a core-shell polymeric nanocarrier with improved relaxometric properties for simultaneous PET/MRI acquisitions. Materials & methods: Core-shell nanoparticles entrapping the Gd-DTPA and 18F-FDG are obtained by a complex coacervation. Results & discussion: The boosting of r1 of the entrapped Gd-DTPA up to five-times compared with 'free Gd-DTPA', is confirmed by the PET/MRI scan. The sorption of 18F-FDG into the nanoparticles is studied and designed to be integrated downstream for the production of the tracer.

Original languageEnglish
Pages (from-to)2223-2231
Number of pages9
JournalNanomedicine
Volume12
Issue number18
DOIs
Publication statusPublished - Sep 1 2017

Keywords

  • dual imaging
  • nanoparticles
  • PET/MRI

ASJC Scopus subject areas

  • Bioengineering
  • Medicine (miscellaneous)
  • Biomedical Engineering
  • Materials Science(all)

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