Hybrid coronary revascularization in multivessel coronary artery disease: a systematic review

Antonio Nenna, Francesco Nappi, Cristiano Spadaccio, Salvatore Matteo Greco, Michele Pilato, Francesco Stilo, Nunzio Montelione, Vincenzo Catanese, Mario Lusini, Francesco Spinelli, Massimo Chello

Research output: Contribution to journalArticlepeer-review


Aim: Hybrid coronary revascularization (HCR) for multivessel coronary artery disease (CAD) integrates coronary artery bypass grafting (CABG) and percutaneous intervention in a planned revascularization strategy. This systematic review summarizes the state of this art of this technique. Methods: Major databases searched until October 2021. Results: The available literature on HCR includes three randomized trials, ten meta-analysis and 27 retrospective studies. The greatest benefits are observed in patients with low-to-intermediate risk and less complex coronary anatomy; highly complex disease and the presence of risk factors favored conventional CABG in terms of adverse events and survival. Conclusion: HCR is an interesting approach for multivessel CAD but should not be considered a 'one-size-fits-all' procedure. Further studies will specify the subset of patients likely to benefit most from this hybrid approach.

Original languageEnglish
JournalFuture Cardiology
Publication statusE-pub ahead of print - Jan 10 2022


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