Hybrid Indocyanine Green–99mTc-nanocolloid for Single-photon Emission Computed Tomography and Combined Radio- and Fluorescence-guided Sentinel Node Biopsy in Penile Cancer: Results of 740 Inguinal Basins Assessed at a Single Institution

Paolo Dell'Oglio; Hielke M. de Vries; Elio Mazzone; Gijs H. KleinJan; Maarten L. Donswijk; Henk G. van der Poel; Simon Horenblas; Fijs W.B. van Leeuwen; Oscar R. Brouwer

doi:10.1016/j.eururo.2020.09.007

Hybrid Indocyanine Green–^99mTc-nanocolloid for Single-photon Emission Computed Tomography and Combined Radio- and Fluorescence-guided Sentinel Node Biopsy in Penile Cancer: Results of 740 Inguinal Basins Assessed at a Single Institution

Paolo Dell'Oglio, Hielke M. de Vries, Elio Mazzone, Gijs H. KleinJan, Maarten L. Donswijk, Henk G. van der Poel, Simon Horenblas, Fijs W.B. van Leeuwen, Oscar R. Brouwer

IRCCS Ospedale San Raffaele

Research output: Contribution to journal › Article › peer-review

Abstract

Indocyanine green (ICG)-^99mTc-nanocolloid is safe and allows for accurate preoperative sentinel node (SN) identification in penile cancer patients, while enabling both intraoperative radio- and fluorescence-guided SN localisation. Fluorescence guidance provided by hybrid ICG-^99mTc-nanocolloid vastly improves intraoperative optical SN identification compared with blue dye.

Original language	English
Pages (from-to)	865-872
Number of pages	8
Journal	European Urology
Volume	78
Issue number	6
DOIs	https://doi.org/10.1016/j.eururo.2020.09.007
Publication status	Published - Dec 2020

Keywords

Blue dye
Fluorescence
Indocyanine green
Penile cancer
Sentinel node

ASJC Scopus subject areas

Urology

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Dell'Oglio, P., de Vries, H. M., Mazzone, E., KleinJan, G. H., Donswijk, M. L., van der Poel, H. G., Horenblas, S., van Leeuwen, F. W. B., & Brouwer, O. R. (2020). Hybrid Indocyanine Green–^99mTc-nanocolloid for Single-photon Emission Computed Tomography and Combined Radio- and Fluorescence-guided Sentinel Node Biopsy in Penile Cancer: Results of 740 Inguinal Basins Assessed at a Single Institution. European Urology, 78(6), 865-872. https://doi.org/10.1016/j.eururo.2020.09.007

Hybrid Indocyanine Green–^99mTc-nanocolloid for Single-photon Emission Computed Tomography and Combined Radio- and Fluorescence-guided Sentinel Node Biopsy in Penile Cancer : Results of 740 Inguinal Basins Assessed at a Single Institution. / Dell'Oglio, Paolo; de Vries, Hielke M.; Mazzone, Elio; KleinJan, Gijs H.; Donswijk, Maarten L.; van der Poel, Henk G.; Horenblas, Simon; van Leeuwen, Fijs W.B.; Brouwer, Oscar R.

In: European Urology, Vol. 78, No. 6, 12.2020, p. 865-872.

Research output: Contribution to journal › Article › peer-review

Dell'Oglio, P, de Vries, HM, Mazzone, E, KleinJan, GH, Donswijk, ML, van der Poel, HG, Horenblas, S, van Leeuwen, FWB & Brouwer, OR 2020, 'Hybrid Indocyanine Green–^99mTc-nanocolloid for Single-photon Emission Computed Tomography and Combined Radio- and Fluorescence-guided Sentinel Node Biopsy in Penile Cancer: Results of 740 Inguinal Basins Assessed at a Single Institution', European Urology, vol. 78, no. 6, pp. 865-872. https://doi.org/10.1016/j.eururo.2020.09.007

Dell'Oglio P, de Vries HM, Mazzone E, KleinJan GH, Donswijk ML, van der Poel HG et al. Hybrid Indocyanine Green–^99mTc-nanocolloid for Single-photon Emission Computed Tomography and Combined Radio- and Fluorescence-guided Sentinel Node Biopsy in Penile Cancer: Results of 740 Inguinal Basins Assessed at a Single Institution. European Urology. 2020 Dec;78(6):865-872. https://doi.org/10.1016/j.eururo.2020.09.007

Dell'Oglio, Paolo ; de Vries, Hielke M. ; Mazzone, Elio ; KleinJan, Gijs H. ; Donswijk, Maarten L. ; van der Poel, Henk G. ; Horenblas, Simon ; van Leeuwen, Fijs W.B. ; Brouwer, Oscar R. / Hybrid Indocyanine Green–^99mTc-nanocolloid for Single-photon Emission Computed Tomography and Combined Radio- and Fluorescence-guided Sentinel Node Biopsy in Penile Cancer : Results of 740 Inguinal Basins Assessed at a Single Institution. In: European Urology. 2020 ; Vol. 78, No. 6. pp. 865-872.

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title = "Hybrid Indocyanine Green–99mTc-nanocolloid for Single-photon Emission Computed Tomography and Combined Radio- and Fluorescence-guided Sentinel Node Biopsy in Penile Cancer: Results of 740 Inguinal Basins Assessed at a Single Institution",

abstract = "Indocyanine green (ICG)-99mTc-nanocolloid is safe and allows for accurate preoperative sentinel node (SN) identification in penile cancer patients, while enabling both intraoperative radio- and fluorescence-guided SN localisation. Fluorescence guidance provided by hybrid ICG-99mTc-nanocolloid vastly improves intraoperative optical SN identification compared with blue dye.",

keywords = "Blue dye, Fluorescence, Indocyanine green, Penile cancer, Sentinel node",

author = "Paolo Dell'Oglio and {de Vries}, {Hielke M.} and Elio Mazzone and KleinJan, {Gijs H.} and Donswijk, {Maarten L.} and {van der Poel}, {Henk G.} and Simon Horenblas and {van Leeuwen}, {Fijs W.B.} and Brouwer, {Oscar R.}",

note = "Funding Information: Other: None. Financial disclosures: Oscar R. Brouwer certifies that all conflicts of interest, including specific financial interests and relationships and affiliations relevant to the subject matter or materials discussed in the manuscript (eg, employment/affiliation, grants or funding, consultancies, honoraria, stock ownership or options, expert testimony, royalties, or patents filed, received, or pending), are the following: None. Funding/Support and role of the sponsor: This research was funded by an ERC starting grant ( ERC-2012-StG-306890 ) and an NWO-TTW-VICI grant ( TTW 16141 ). Acknowledgements: We want to thank Lieke Wever for assisting in data collection and our local statistician Vincent van der Noort for the statistical advice. Publisher Copyright: {\textcopyright} 2020 European Association of Urology Copyright: Copyright 2020 Elsevier B.V., All rights reserved.",

year = "2020",

month = dec,

doi = "10.1016/j.eururo.2020.09.007",

language = "English",

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AU - Dell'Oglio, Paolo

AU - de Vries, Hielke M.

AU - Mazzone, Elio

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AU - van der Poel, Henk G.

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PY - 2020/12

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