Hybrid lymphoid blast crisis of chronic myeloid leukemia with both immunoglobulin and T-cell receptor gene rearrangements

F. Morabito, V. Callea, B. Oliva, P. F. Di Celle, A. Carbone, F. Nobile, R. Foa

Research output: Contribution to journalArticle

Abstract

A case of Ph1+ chronic myeloid leukemia in blast crisis (CML-BC) is reported, in which the periodic acid Schiff and myeloperoxidase negative blasts displayed high terminal deoxynucleotidyl activity and coexpressed both B- (CD19, CD10, and CD24) and T- (CD7) lymphoid markers. In line with the immunophenotype, DNA analysis revealed a rearranged configuration of both the immunoglobulin and T-cell receptor (beta, gamma, and delta) genes. In spite of this dual B/T phenotype and genotype, the negativity of CyCD3 favors the suggestion that the target of the neoplastic event is an early B cell, with a cross lineage involvement of the putative common recombinase. However, taking into account that a normal counterpart of a biphenotypic B/T ALL has been recognized, it could be hypothesized that the leukemic transformation may have involved an oligopotent B/T lymphoid precursor. This case confirms the lineage heterogeneity of CML-BC and suggests that DNA analyses coupled to extensive immunophenotyping may allow further insight for a more precise recognition of both normal and leukemic ontogenesis.

Original languageEnglish
Pages (from-to)119-124
Number of pages6
JournalHematologic Pathology
Volume5
Issue number3
Publication statusPublished - 1991

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T-Lymphocyte Gene Rearrangement
Blast Crisis
T-Cell Receptor Genes
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Immunoglobulins
Antigen Receptors, T-Cell, gamma-delta
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Immunophenotyping
Recombinases
Periodic Acid
DNA
Peroxidase
B-Lymphocytes
Genotype
Phenotype
Genes

ASJC Scopus subject areas

  • Hematology
  • Pathology and Forensic Medicine

Cite this

Morabito, F., Callea, V., Oliva, B., Di Celle, P. F., Carbone, A., Nobile, F., & Foa, R. (1991). Hybrid lymphoid blast crisis of chronic myeloid leukemia with both immunoglobulin and T-cell receptor gene rearrangements. Hematologic Pathology, 5(3), 119-124.

Hybrid lymphoid blast crisis of chronic myeloid leukemia with both immunoglobulin and T-cell receptor gene rearrangements. / Morabito, F.; Callea, V.; Oliva, B.; Di Celle, P. F.; Carbone, A.; Nobile, F.; Foa, R.

In: Hematologic Pathology, Vol. 5, No. 3, 1991, p. 119-124.

Research output: Contribution to journalArticle

Morabito, F, Callea, V, Oliva, B, Di Celle, PF, Carbone, A, Nobile, F & Foa, R 1991, 'Hybrid lymphoid blast crisis of chronic myeloid leukemia with both immunoglobulin and T-cell receptor gene rearrangements', Hematologic Pathology, vol. 5, no. 3, pp. 119-124.
Morabito, F. ; Callea, V. ; Oliva, B. ; Di Celle, P. F. ; Carbone, A. ; Nobile, F. ; Foa, R. / Hybrid lymphoid blast crisis of chronic myeloid leukemia with both immunoglobulin and T-cell receptor gene rearrangements. In: Hematologic Pathology. 1991 ; Vol. 5, No. 3. pp. 119-124.
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