Hybrid quadrupole time-of-flight for the determination of chlorophenols in surface water by liquid chromatography-tandem mass spectrometry

S. Marchese, A. Gentili, D. Perret, M. Sergi, S. Notari

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

A QSTAR Pulsar quadrupole time-of-flight mass spectrometer was used for the determination of chlorophenols in surface water samples. The investigated compounds were: 2-chlorophenol; 4-chloro-3-methylphenol; 2,4-dichlorophenol, 2,4,6-trichlorophenol and pentachlorophenol. Each analyte is listed by the US-EPA as a priority pollutant. Sample enrichment of water samples was achieved by a solid-phase extraction procedure, using a Waters Oasis HLB cartridges followed by LC-Tandem-MS. A narrow-bore 2.1-mm-i.d. reversed phase LC C-18 column operating with a mobile phase flow rate of 0.2 mL min -1, was used to separate the analytes. The whole column effluent was diverted to the ion spray interface source. For the determination of the analytes the hybrid quadrupole time-of-flight spectrometer operated in product ion scan acquisition mode. Average recoveries from 2 L samples varied from 91 to 110% and relative standard deviations (RSD) were less than 10% for all samples. The limit of detection (signal-to-noise ratio=3) of the method for the phenols in drinking water samples is less than 10 ng L -1. In real environmental samples, levels of the selected analytes varied from "non-detected" up to 0.5 μg L -1 for pentachlorophenol.

Original languageEnglish
Pages (from-to)411-417
Number of pages7
JournalChromatographia
Volume59
Issue number7-8
Publication statusPublished - Apr 2004

Fingerprint

Chlorophenols
Pentachlorophenol
Liquid chromatography
Tandem Mass Spectrometry
Surface waters
Liquid Chromatography
Mass spectrometry
Ions
DEAE-Dextran
Water
Phenols
Mass spectrometers
Drinking Water
Spectrometers
Effluents
Signal to noise ratio
Solid Phase Extraction
Flow rate
Signal-To-Noise Ratio
Recovery

Keywords

  • Chlorophenols
  • Column liquid chromatography-tandem-MS
  • Surface water analysis

ASJC Scopus subject areas

  • Analytical Chemistry
  • Clinical Biochemistry

Cite this

Hybrid quadrupole time-of-flight for the determination of chlorophenols in surface water by liquid chromatography-tandem mass spectrometry. / Marchese, S.; Gentili, A.; Perret, D.; Sergi, M.; Notari, S.

In: Chromatographia, Vol. 59, No. 7-8, 04.2004, p. 411-417.

Research output: Contribution to journalArticle

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AB - A QSTAR Pulsar quadrupole time-of-flight mass spectrometer was used for the determination of chlorophenols in surface water samples. The investigated compounds were: 2-chlorophenol; 4-chloro-3-methylphenol; 2,4-dichlorophenol, 2,4,6-trichlorophenol and pentachlorophenol. Each analyte is listed by the US-EPA as a priority pollutant. Sample enrichment of water samples was achieved by a solid-phase extraction procedure, using a Waters Oasis HLB cartridges followed by LC-Tandem-MS. A narrow-bore 2.1-mm-i.d. reversed phase LC C-18 column operating with a mobile phase flow rate of 0.2 mL min -1, was used to separate the analytes. The whole column effluent was diverted to the ion spray interface source. For the determination of the analytes the hybrid quadrupole time-of-flight spectrometer operated in product ion scan acquisition mode. Average recoveries from 2 L samples varied from 91 to 110% and relative standard deviations (RSD) were less than 10% for all samples. The limit of detection (signal-to-noise ratio=3) of the method for the phenols in drinking water samples is less than 10 ng L -1. In real environmental samples, levels of the selected analytes varied from "non-detected" up to 0.5 μg L -1 for pentachlorophenol.

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