Hydrogel-Terminated Photonic Crystal for Label-Free Detection of Angiopoietin-1

Francesca Frascella, Christian Petri, Serena Ricciardi, Lucia Napione, Peter Munzert, Ulrich Jonas, Jakub Dostalek, Federico Bussolino, Candido Fabrizio Pirri, Emiliano Descrovi

Research output: Contribution to journalArticlepeer-review

Abstract

We report on a label-free time-resolved biosensing technique based on refractometric measurements. A one-dimensional photonic crystal (1-DPC) constituted by a planar stack of dielectric layers is used for supporting Bloch surface waves. These electromagnetic surface waves probe the aqueous environment within few hundreds of nanometers from the photonic crystal surface, which is functionalized with a hydrogel binding matrix. Therein, selected antibodies are grafted for the specific recognition of the tumoral biomarker Angiopoietin-1. A model bioassay is established demonstrating a detection of Antiopoiegin-1 as low as picomolar concentrations.

Original languageEnglish
Article number7409927
Pages (from-to)3641-3645
Number of pages5
JournalJournal of Lightwave Technology
Volume34
Issue number15
DOIs
Publication statusPublished - Aug 1 2016

Keywords

  • Dextran hydrogel
  • label-free biosensing
  • photonic crystals
  • surface waves

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics

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