Hydrogen peroxide: A metabolic by-product or a common mediator of ageing signals?

Research output: Contribution to journalArticlepeer-review

Abstract

The reactive oxygen species that are generated by mitochondrial respiration, including hydrogen peroxide (H2O2), are potent inducers of oxidative damage and mediators of ageing. It is not clear, however, whether oxidative stress is the result of a genetic programme or the by-product of physiological processes. Recent findings demonstrate that a fraction of mitochondrial H2O2, produced by a specialized enzyme as a signalling molecule in the pathway of apoptosis, induces intracellular oxidative stress and accelerates ageing. We propose that genes that control H2O2 production are selected determinants of lifespan.

Original languageEnglish
Pages (from-to)722-728
Number of pages7
JournalNature Reviews Molecular Cell Biology
Volume8
Issue number9
DOIs
Publication statusPublished - Sep 2007

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology

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