Hydrogen Sulfide in Bone Tissue Regeneration and Repair: State of the Art and New Perspectives

Research output: Contribution to journalReview article

Abstract

The importance of hydrogen sulfide (H2S) in the regulation of multiple physiological functions has been clearly recognized in the over 20 years since it was first identified as a novel gasotransmitter. In bone tissue H2S exerts a cytoprotective effect and promotes bone formation. Just recently, the scientific community has begun to appreciate its role as a therapeutic agent in bone pathologies. Pharmacological administration of H2S achieved encouraging results in preclinical studies in the treatment of systemic bone diseases, such as osteoporosis; however, a local delivery of H2S at sites of bone damage may provide additional opportunities of treatment. Here, we highlight how H2S stimulates multiple signaling pathways involved in various stages of the processes of bone repair. Moreover, we discuss how material science and chemistry have recently developed biomaterials and H2S-donors with improved features, laying the ground for the development of H2S-releasing devices for bone regenerative medicine. This review is intended to give a state-of-the-art description of the pro-regenerative properties of H2S, with a focus on bone tissue, and to discuss the potential of H2S-releasing scaffolds as a support for bone repair.

Original languageEnglish
Number of pages19
JournalInternational Journal of Molecular Sciences
Volume20
Issue number20
DOIs
Publication statusPublished - Oct 22 2019

Fingerprint

Tissue regeneration
Hydrogen Sulfide
Bone Regeneration
hydrogen sulfide
Hydrogen sulfide
regeneration
bones
Bone
Repair
Bone and Bones
releasing
Gasotransmitters
Regenerative Medicine
osteoporosis
osteogenesis
Bone Diseases
Tissue
Biocompatible Materials
Osteogenesis
pathology

Keywords

  • H2S-releasing scaffolds
  • bone tissue regeneration
  • cell recruitment
  • endochondral ossification
  • hydrogen sulfide
  • inflammation
  • osteogenesis
  • tissue engineering
  • vasculogenesis

Cite this

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title = "Hydrogen Sulfide in Bone Tissue Regeneration and Repair: State of the Art and New Perspectives",
abstract = "The importance of hydrogen sulfide (H2S) in the regulation of multiple physiological functions has been clearly recognized in the over 20 years since it was first identified as a novel gasotransmitter. In bone tissue H2S exerts a cytoprotective effect and promotes bone formation. Just recently, the scientific community has begun to appreciate its role as a therapeutic agent in bone pathologies. Pharmacological administration of H2S achieved encouraging results in preclinical studies in the treatment of systemic bone diseases, such as osteoporosis; however, a local delivery of H2S at sites of bone damage may provide additional opportunities of treatment. Here, we highlight how H2S stimulates multiple signaling pathways involved in various stages of the processes of bone repair. Moreover, we discuss how material science and chemistry have recently developed biomaterials and H2S-donors with improved features, laying the ground for the development of H2S-releasing devices for bone regenerative medicine. This review is intended to give a state-of-the-art description of the pro-regenerative properties of H2S, with a focus on bone tissue, and to discuss the potential of H2S-releasing scaffolds as a support for bone repair.",
keywords = "H2S-releasing scaffolds, bone tissue regeneration, cell recruitment, endochondral ossification, hydrogen sulfide, inflammation, osteogenesis, tissue engineering, vasculogenesis",
author = "Laura Gambari and Brunella Grigolo and Francesco Grassi",
year = "2019",
month = "10",
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doi = "10.3390/ijms20205231",
language = "English",
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journal = "International Journal of Molecular Sciences",
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T1 - Hydrogen Sulfide in Bone Tissue Regeneration and Repair: State of the Art and New Perspectives

AU - Gambari, Laura

AU - Grigolo, Brunella

AU - Grassi, Francesco

PY - 2019/10/22

Y1 - 2019/10/22

N2 - The importance of hydrogen sulfide (H2S) in the regulation of multiple physiological functions has been clearly recognized in the over 20 years since it was first identified as a novel gasotransmitter. In bone tissue H2S exerts a cytoprotective effect and promotes bone formation. Just recently, the scientific community has begun to appreciate its role as a therapeutic agent in bone pathologies. Pharmacological administration of H2S achieved encouraging results in preclinical studies in the treatment of systemic bone diseases, such as osteoporosis; however, a local delivery of H2S at sites of bone damage may provide additional opportunities of treatment. Here, we highlight how H2S stimulates multiple signaling pathways involved in various stages of the processes of bone repair. Moreover, we discuss how material science and chemistry have recently developed biomaterials and H2S-donors with improved features, laying the ground for the development of H2S-releasing devices for bone regenerative medicine. This review is intended to give a state-of-the-art description of the pro-regenerative properties of H2S, with a focus on bone tissue, and to discuss the potential of H2S-releasing scaffolds as a support for bone repair.

AB - The importance of hydrogen sulfide (H2S) in the regulation of multiple physiological functions has been clearly recognized in the over 20 years since it was first identified as a novel gasotransmitter. In bone tissue H2S exerts a cytoprotective effect and promotes bone formation. Just recently, the scientific community has begun to appreciate its role as a therapeutic agent in bone pathologies. Pharmacological administration of H2S achieved encouraging results in preclinical studies in the treatment of systemic bone diseases, such as osteoporosis; however, a local delivery of H2S at sites of bone damage may provide additional opportunities of treatment. Here, we highlight how H2S stimulates multiple signaling pathways involved in various stages of the processes of bone repair. Moreover, we discuss how material science and chemistry have recently developed biomaterials and H2S-donors with improved features, laying the ground for the development of H2S-releasing devices for bone regenerative medicine. This review is intended to give a state-of-the-art description of the pro-regenerative properties of H2S, with a focus on bone tissue, and to discuss the potential of H2S-releasing scaffolds as a support for bone repair.

KW - H2S-releasing scaffolds

KW - bone tissue regeneration

KW - cell recruitment

KW - endochondral ossification

KW - hydrogen sulfide

KW - inflammation

KW - osteogenesis

KW - tissue engineering

KW - vasculogenesis

U2 - 10.3390/ijms20205231

DO - 10.3390/ijms20205231

M3 - Review article

C2 - 31652532

VL - 20

JO - International Journal of Molecular Sciences

JF - International Journal of Molecular Sciences

SN - 1661-6596

IS - 20

ER -