Abstract
Gaseous mediators such as nitric oxide (NO) play a major regulatory role in the cardiovascular system homeostasis, including platelet aggregation. Here, we investigated whether hydrogen sulfide (H2S), a newly recognized endogenous mediator, can affects aggregation of human platelets, using sodium hydrogen sulfide (NaHS) as H2S-donor. NaHS inhibited platelet aggregation induced by ADP, collagen, epinephrine, arachidonic acid, thromboxane mimetic, U46619, and thrombin. H2S effect was not dependent by cAMP/cGMP generation, NO production or potassium-channels opening. NaHS concentrations (up to 10 mM) did not exert toxic effects on platelet viability. The possible protective role of endogenous H2S in cardiovascular system is discussed.
| Original language | English |
|---|---|
| Pages (from-to) | 65-68 |
| Number of pages | 4 |
| Journal | European Journal of Pharmacology |
| Volume | 559 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Mar 15 2007 |
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Keywords
- Cardiovascular risk factor
- HS
- Hydrogen sulfide
- Platelet inhibition
- Thromboembolic disease
ASJC Scopus subject areas
- Cellular and Molecular Neuroscience
- Pharmacology
Cite this
Hydrogen sulfide inhibits human platelet aggregation. / Zagli, Giovanni; Patacchini, Riccardo; Trevisani, Marcello; Abbate, Rosanna; Cinotti, Sandro; Gensini, Gian Franco; Masotti, Giulio; Geppetti, Pierangelo.
In: European Journal of Pharmacology, Vol. 559, No. 1, 15.03.2007, p. 65-68.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Hydrogen sulfide inhibits human platelet aggregation
AU - Zagli, Giovanni
AU - Patacchini, Riccardo
AU - Trevisani, Marcello
AU - Abbate, Rosanna
AU - Cinotti, Sandro
AU - Gensini, Gian Franco
AU - Masotti, Giulio
AU - Geppetti, Pierangelo
PY - 2007/3/15
Y1 - 2007/3/15
N2 - Gaseous mediators such as nitric oxide (NO) play a major regulatory role in the cardiovascular system homeostasis, including platelet aggregation. Here, we investigated whether hydrogen sulfide (H2S), a newly recognized endogenous mediator, can affects aggregation of human platelets, using sodium hydrogen sulfide (NaHS) as H2S-donor. NaHS inhibited platelet aggregation induced by ADP, collagen, epinephrine, arachidonic acid, thromboxane mimetic, U46619, and thrombin. H2S effect was not dependent by cAMP/cGMP generation, NO production or potassium-channels opening. NaHS concentrations (up to 10 mM) did not exert toxic effects on platelet viability. The possible protective role of endogenous H2S in cardiovascular system is discussed.
AB - Gaseous mediators such as nitric oxide (NO) play a major regulatory role in the cardiovascular system homeostasis, including platelet aggregation. Here, we investigated whether hydrogen sulfide (H2S), a newly recognized endogenous mediator, can affects aggregation of human platelets, using sodium hydrogen sulfide (NaHS) as H2S-donor. NaHS inhibited platelet aggregation induced by ADP, collagen, epinephrine, arachidonic acid, thromboxane mimetic, U46619, and thrombin. H2S effect was not dependent by cAMP/cGMP generation, NO production or potassium-channels opening. NaHS concentrations (up to 10 mM) did not exert toxic effects on platelet viability. The possible protective role of endogenous H2S in cardiovascular system is discussed.
KW - Cardiovascular risk factor
KW - HS
KW - Hydrogen sulfide
KW - Platelet inhibition
KW - Thromboembolic disease
UR - http://www.scopus.com/inward/record.url?scp=33847078111&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33847078111&partnerID=8YFLogxK
U2 - 10.1016/j.ejphar.2006.12.011
DO - 10.1016/j.ejphar.2006.12.011
M3 - Article
C2 - 17291489
AN - SCOPUS:33847078111
VL - 559
SP - 65
EP - 68
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
SN - 0014-2999
IS - 1
ER -