Hydrogen sulfide inhibits human platelet aggregation

Giovanni Zagli, Riccardo Patacchini, Marcello Trevisani, Rosanna Abbate, Sandro Cinotti, Gian Franco Gensini, Giulio Masotti, Pierangelo Geppetti

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

Gaseous mediators such as nitric oxide (NO) play a major regulatory role in the cardiovascular system homeostasis, including platelet aggregation. Here, we investigated whether hydrogen sulfide (H2S), a newly recognized endogenous mediator, can affects aggregation of human platelets, using sodium hydrogen sulfide (NaHS) as H2S-donor. NaHS inhibited platelet aggregation induced by ADP, collagen, epinephrine, arachidonic acid, thromboxane mimetic, U46619, and thrombin. H2S effect was not dependent by cAMP/cGMP generation, NO production or potassium-channels opening. NaHS concentrations (up to 10 mM) did not exert toxic effects on platelet viability. The possible protective role of endogenous H2S in cardiovascular system is discussed.

Original languageEnglish
Pages (from-to)65-68
Number of pages4
JournalEuropean Journal of Pharmacology
Volume559
Issue number1
DOIs
Publication statusPublished - Mar 15 2007

Fingerprint

Hydrogen Sulfide
Platelet Aggregation
Cardiovascular System
Nitric Oxide
Gasotransmitters
15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid
Poisons
Thromboxanes
Potassium Channels
Arachidonic Acid
Thrombin
Adenosine Diphosphate
Epinephrine
Homeostasis
Collagen
Blood Platelets
sodium bisulfide

Keywords

  • Cardiovascular risk factor
  • HS
  • Hydrogen sulfide
  • Platelet inhibition
  • Thromboembolic disease

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

Cite this

Zagli, G., Patacchini, R., Trevisani, M., Abbate, R., Cinotti, S., Gensini, G. F., ... Geppetti, P. (2007). Hydrogen sulfide inhibits human platelet aggregation. European Journal of Pharmacology, 559(1), 65-68. https://doi.org/10.1016/j.ejphar.2006.12.011

Hydrogen sulfide inhibits human platelet aggregation. / Zagli, Giovanni; Patacchini, Riccardo; Trevisani, Marcello; Abbate, Rosanna; Cinotti, Sandro; Gensini, Gian Franco; Masotti, Giulio; Geppetti, Pierangelo.

In: European Journal of Pharmacology, Vol. 559, No. 1, 15.03.2007, p. 65-68.

Research output: Contribution to journalArticle

Zagli, G, Patacchini, R, Trevisani, M, Abbate, R, Cinotti, S, Gensini, GF, Masotti, G & Geppetti, P 2007, 'Hydrogen sulfide inhibits human platelet aggregation', European Journal of Pharmacology, vol. 559, no. 1, pp. 65-68. https://doi.org/10.1016/j.ejphar.2006.12.011
Zagli G, Patacchini R, Trevisani M, Abbate R, Cinotti S, Gensini GF et al. Hydrogen sulfide inhibits human platelet aggregation. European Journal of Pharmacology. 2007 Mar 15;559(1):65-68. https://doi.org/10.1016/j.ejphar.2006.12.011
Zagli, Giovanni ; Patacchini, Riccardo ; Trevisani, Marcello ; Abbate, Rosanna ; Cinotti, Sandro ; Gensini, Gian Franco ; Masotti, Giulio ; Geppetti, Pierangelo. / Hydrogen sulfide inhibits human platelet aggregation. In: European Journal of Pharmacology. 2007 ; Vol. 559, No. 1. pp. 65-68.
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