Hydromethanolic Extracts from Adansonia digitata L. Edible Parts Positively Modulate Pathophysiological Mechanisms Related to the Metabolic Syndrome

Stefania Cicolari, Marco Dacrema, Arold Jorel Tsetegho Sokeng, Jianbo Xiao, Achille Parfait Atchan Nwakiban, Carmen Di Giovanni, Cristina Santarcangelo, Paolo Magni, Maria Daglia

Research output: Contribution to journalArticlepeer-review

Abstract

Metabolic syndrome includes a cluster of risk factors for many pathological conditions, including hyperglycemia, abdominal obesity, hyperlipidemia, and hypertension. Adansonia digitata L. (also known as baobab) is used in traditional African Medicine and recent studies showed that it improves the metabolism of carbohydrates and lipids. The aim of this study is to investigate the mechanisms of action associated with the beneficial effects of extracts from the edible parts of baobab (fruit pulp, leaves, raw and toasted seeds), evaluating their inhibitory activity against: alpha-amylase, alpha-glucosidase, angiotensin-converting enzyme, 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase, and pancreatic lipase. Baobab fruit pulp and leaf extracts resulted to be the most active ones and were then tested on the differentiation process of SW-872 human liposarcoma cells to mature adipocytes. The addition of these latter extracts did not affect triglyceride accumulation, indicating a neutral impact on this parameter. The findings here reported help to explain the growing amount of evidence on the biological properties of baobab and provide suggestions about their use in food and nutraceutical fields.

Original languageEnglish
Article number2858
JournalMolecules
Volume25
Issue number12
DOIs
Publication statusPublished - Jun 2020

Keywords

  • ACE inhibition
  • Adansonia digitata L
  • Baobab edible parts
  • Digestive enzyme inhibition
  • HMG-CoA reductase inhibition
  • SW-872 preadipocytes

ASJC Scopus subject areas

  • Analytical Chemistry
  • Chemistry (miscellaneous)
  • Molecular Medicine
  • Pharmaceutical Science
  • Drug Discovery
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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