Hydroxamate inhibitors of Aeromonas hydrophila AE036 metallo-β- lactamase

Magnus W. Walter, Maria Hernandez Valladares, Robert M. Adlington, Gianfranco Amicosante, Jack E. Baldwin, Jean Marie Frère, Moreno Galleni, Gian Maria Rossolini, Christopher J. Schofield

Research output: Contribution to journalArticlepeer-review

Abstract

Amino acid derived hydroxamates were synthesized and tested for inhibitory activity against different metallo-β-lactamases. Several compounds inhibited the clinically relevant enzyme from Aeromonas hydrophila AE036.

Original languageEnglish
Pages (from-to)35-40
Number of pages6
JournalBioorganic Chemistry
Volume27
Issue number1
DOIs
Publication statusPublished - Feb 1999

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery

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