Hydroxyapatite-coated orthopaedic screws as infection resistant materials: In vitro study

Carla Renata Arciola, Lucio Montanaro, Antonio Moroni, Michele Giordano, Arturo Pizzoferrato, Maria Elena Donati

Research output: Contribution to journalArticlepeer-review

Abstract

The authors evaluated in vitro the adherence of a Staphylococcus epidermidis strain to hydroxyapatite-coated stainless-steel screws - used in orthopaedic surgery for external fracture fixation - in comparison with the adherence to uncoated screws. Evaluations were also performed on analogous groups of screws immersed for 72 and 168 h in a solution at 37°C, in order to simulate the interstitial fluid in a simplified way. Adherence values on coated prostheses resulted significantly lower compared with those observed on metal prostheses, both in basal conditions and after immersion in saline solution. Moreover, both on coated and on uncoated screws a significant reduction in bacterial adherence was noted related to the duration of the prosthesis permanence in saline solution.

Original languageEnglish
Pages (from-to)323-327
Number of pages5
JournalBiomaterials
Volume20
Issue number4
DOIs
Publication statusPublished - Feb 1999

Keywords

  • Bacterial adherence
  • Hydroxyapatite
  • Infection resistant material
  • Orthopaedic screws
  • Stainless steel

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biomedical Engineering

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