Hydroxyapatite-coated polycaprolacton wide mesh as a model of open structure for bone regeneration

Silvia Scaglione, Cristina Ilengo, Marco Fato, Rodolfo Quarto

Research output: Contribution to journalArticle

Abstract

In principle, three-dimensional (3D) osteoconductive grafts with a proper chemical composition, high total porosity, and fully interconnected pores are suitable carriers to provide a proper substrate for in vivo neobone tissue ingrowth. However, most porous materials carry some intrinsic limits because of their internal structure (i.e., limited macroporosity and small pore interconnection size), representing a physical constraint for a massive blood afflux and bone ingrowth and therefore for generating effective osteopermissive grafts. We therefore hypothesized that an unconventional scaffold, based on an "open-structure" concept, should not pose any limit to vascularization of grafts and consequently to the amount of bone growth. Starting from this hypothesis, we have designed and developed a 3D osteoconductive polymeric-based wide-net mesh. Polymer fibers, joining hydroxyapatite beads, were coated with a thin layer of calcium phosphate (Ca-P), coupling the osteoconductivity properties of Ca-P with the handness and bulk properties of polymers. This completely open 3D scaffold prototype was tested both in vitro and in vivo, displaying a promising in vivo blood vessel invasion and bone-forming efficiency.

Original languageEnglish
Pages (from-to)155-163
Number of pages9
JournalTissue Engineering - Part A
Volume15
Issue number1
DOIs
Publication statusPublished - Jan 1 2009

Fingerprint

Bone Regeneration
Durapatite
Hydroxyapatite
Grafts
Bone
Calcium phosphate
Transplants
Scaffolds
Polymers
Bone and Bones
Porosity
Bone Development
Blood vessels
Joining
Blood Vessels
Porous materials
Blood
Tissue
Fibers
Substrates

ASJC Scopus subject areas

  • Bioengineering
  • Biochemistry
  • Biomedical Engineering
  • Biomaterials

Cite this

Hydroxyapatite-coated polycaprolacton wide mesh as a model of open structure for bone regeneration. / Scaglione, Silvia; Ilengo, Cristina; Fato, Marco; Quarto, Rodolfo.

In: Tissue Engineering - Part A, Vol. 15, No. 1, 01.01.2009, p. 155-163.

Research output: Contribution to journalArticle

Scaglione, Silvia ; Ilengo, Cristina ; Fato, Marco ; Quarto, Rodolfo. / Hydroxyapatite-coated polycaprolacton wide mesh as a model of open structure for bone regeneration. In: Tissue Engineering - Part A. 2009 ; Vol. 15, No. 1. pp. 155-163.
@article{67079e4a39b5405384ada4a1830e677a,
title = "Hydroxyapatite-coated polycaprolacton wide mesh as a model of open structure for bone regeneration",
abstract = "In principle, three-dimensional (3D) osteoconductive grafts with a proper chemical composition, high total porosity, and fully interconnected pores are suitable carriers to provide a proper substrate for in vivo neobone tissue ingrowth. However, most porous materials carry some intrinsic limits because of their internal structure (i.e., limited macroporosity and small pore interconnection size), representing a physical constraint for a massive blood afflux and bone ingrowth and therefore for generating effective osteopermissive grafts. We therefore hypothesized that an unconventional scaffold, based on an {"}open-structure{"} concept, should not pose any limit to vascularization of grafts and consequently to the amount of bone growth. Starting from this hypothesis, we have designed and developed a 3D osteoconductive polymeric-based wide-net mesh. Polymer fibers, joining hydroxyapatite beads, were coated with a thin layer of calcium phosphate (Ca-P), coupling the osteoconductivity properties of Ca-P with the handness and bulk properties of polymers. This completely open 3D scaffold prototype was tested both in vitro and in vivo, displaying a promising in vivo blood vessel invasion and bone-forming efficiency.",
author = "Silvia Scaglione and Cristina Ilengo and Marco Fato and Rodolfo Quarto",
year = "2009",
month = "1",
day = "1",
doi = "10.1089/ten.tea.2007.0410",
language = "English",
volume = "15",
pages = "155--163",
journal = "Tissue Engineering - Part A.",
issn = "1937-3341",
publisher = "Mary Ann Liebert Inc.",
number = "1",

}

TY - JOUR

T1 - Hydroxyapatite-coated polycaprolacton wide mesh as a model of open structure for bone regeneration

AU - Scaglione, Silvia

AU - Ilengo, Cristina

AU - Fato, Marco

AU - Quarto, Rodolfo

PY - 2009/1/1

Y1 - 2009/1/1

N2 - In principle, three-dimensional (3D) osteoconductive grafts with a proper chemical composition, high total porosity, and fully interconnected pores are suitable carriers to provide a proper substrate for in vivo neobone tissue ingrowth. However, most porous materials carry some intrinsic limits because of their internal structure (i.e., limited macroporosity and small pore interconnection size), representing a physical constraint for a massive blood afflux and bone ingrowth and therefore for generating effective osteopermissive grafts. We therefore hypothesized that an unconventional scaffold, based on an "open-structure" concept, should not pose any limit to vascularization of grafts and consequently to the amount of bone growth. Starting from this hypothesis, we have designed and developed a 3D osteoconductive polymeric-based wide-net mesh. Polymer fibers, joining hydroxyapatite beads, were coated with a thin layer of calcium phosphate (Ca-P), coupling the osteoconductivity properties of Ca-P with the handness and bulk properties of polymers. This completely open 3D scaffold prototype was tested both in vitro and in vivo, displaying a promising in vivo blood vessel invasion and bone-forming efficiency.

AB - In principle, three-dimensional (3D) osteoconductive grafts with a proper chemical composition, high total porosity, and fully interconnected pores are suitable carriers to provide a proper substrate for in vivo neobone tissue ingrowth. However, most porous materials carry some intrinsic limits because of their internal structure (i.e., limited macroporosity and small pore interconnection size), representing a physical constraint for a massive blood afflux and bone ingrowth and therefore for generating effective osteopermissive grafts. We therefore hypothesized that an unconventional scaffold, based on an "open-structure" concept, should not pose any limit to vascularization of grafts and consequently to the amount of bone growth. Starting from this hypothesis, we have designed and developed a 3D osteoconductive polymeric-based wide-net mesh. Polymer fibers, joining hydroxyapatite beads, were coated with a thin layer of calcium phosphate (Ca-P), coupling the osteoconductivity properties of Ca-P with the handness and bulk properties of polymers. This completely open 3D scaffold prototype was tested both in vitro and in vivo, displaying a promising in vivo blood vessel invasion and bone-forming efficiency.

UR - http://www.scopus.com/inward/record.url?scp=58149218414&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=58149218414&partnerID=8YFLogxK

U2 - 10.1089/ten.tea.2007.0410

DO - 10.1089/ten.tea.2007.0410

M3 - Article

C2 - 18657026

AN - SCOPUS:58149218414

VL - 15

SP - 155

EP - 163

JO - Tissue Engineering - Part A.

JF - Tissue Engineering - Part A.

SN - 1937-3341

IS - 1

ER -