Hydroxyl radical production and DNA damage induced by anthracycline-iron complex

Josephia R F Muindi, Birandra K. Sinha, Luca Gianni, Charles E. Myers

Research output: Contribution to journalArticlepeer-review

Abstract

Adriamycin-Fe3+ complex catalyzes the formation of hydroxyl radical from hydrogen peroxide but the DNA-adriamycin-iron ternary complex is much more effective. 11-Deoxyadriamycin, which shows no spectral evidence of complex formation with iron, was ineffective. The generation of hydroxyl radical by adriamycin-Fe3+ complex in the presence of DNA correlates with its ability to cleave DNA. Hydroxyl radicals are thus implicated as the reactive oxygen species involved in the DNA damage caused by the adriamycin-Fe3+ complex.

Original languageEnglish
Pages (from-to)226-230
Number of pages5
JournalFEBS Letters
Volume172
Issue number2
DOIs
Publication statusPublished - Jul 9 1984

Keywords

  • Anthracycline-iron complex
  • DNA damage
  • Hydroxyl radical
  • Spin trapping

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

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