Abstract
Three structurally related benzodiazepines were studied as substrates for hydroxylation by liver microsomal enzymes of rats and mice. The V(max) was comparable for dechlorodesmethyldiazepam, desmethyldiazepam, and 2' chlorodesmethyldiazepam in the 2 animal species. The apparent K(m) decreased from dechlorodesmethyldiazepam to 2' chlorodesmethyldiazepam for liver microsomal enzymes from both animal species. The hydroxylation of desmethyldiazepam and 2' chlorodesmethyldiazepam yielded 2 pharmacologically active metabolites, oxazepam and lorazepam, respectively.
| Original language | English |
|---|---|
| Pages (from-to) | 1482-1483 |
| Number of pages | 2 |
| Journal | Journal of Pharmaceutical Sciences |
| Volume | 66 |
| Issue number | 10 |
| Publication status | Published - 1977 |
ASJC Scopus subject areas
- Drug Discovery
- Organic Chemistry
- Chemistry(all)
- Molecular Medicine
- Pharmacology
- Pharmaceutical Science