TY - JOUR
T1 - Hydroxytyrosol attenuates peripheral neuropathy in streptozotocin-induced diabetes in rats
AU - Ristagno, Giuseppe
AU - Fumagalli, Francesca
AU - Porretta-Serapiglia, Carla
AU - Orrù, Alessandro
AU - Cassina, Chiara
AU - Pesaresi, Marzia
AU - Masson, Serge
AU - Villanova, Luciano
AU - Merendino, Alessandro
AU - Villanova, Azzurra
AU - Cervo, Luigi
AU - Lauria, Giuseppe
AU - Latini, Roberto
AU - Bianchi, Roberto
PY - 2012/6/13
Y1 - 2012/6/13
N2 - Peripheral neuropathy is one of the most frequent and severe complications of diabetes. Hydroxytyrosol (HT), the major antioxidant polyphenolic compound of olive oil, has been investigated as a new potential treatment to counteract the progression of peripheral diabetic neuropathy in rats. An established model of streptozotocin-induced diabetes has been used. After confirmation of hyperglycemia, diabetic and nondiabetic animals were randomized to receive either a low dose or a high dose of HT, or the corresponding vehicle, for 6 weeks. At the end of the 6-week period of treatment, HT blunted plasma thiobarbituric acid-reactive substances increase (p <0.05) and significantly reduced nerve conduction velocity (p <0.05) and thermal nociception impairment in diabetic rats (p <0.05). Sciatic nerve Na+, K +-ATPase activity reduction was also abolished by HT (p <0.05). The present study provides evidence of the therapeutic potential of the natural substance hydroxytyrosol in the early stage of diabetic neuropathy.
AB - Peripheral neuropathy is one of the most frequent and severe complications of diabetes. Hydroxytyrosol (HT), the major antioxidant polyphenolic compound of olive oil, has been investigated as a new potential treatment to counteract the progression of peripheral diabetic neuropathy in rats. An established model of streptozotocin-induced diabetes has been used. After confirmation of hyperglycemia, diabetic and nondiabetic animals were randomized to receive either a low dose or a high dose of HT, or the corresponding vehicle, for 6 weeks. At the end of the 6-week period of treatment, HT blunted plasma thiobarbituric acid-reactive substances increase (p <0.05) and significantly reduced nerve conduction velocity (p <0.05) and thermal nociception impairment in diabetic rats (p <0.05). Sciatic nerve Na+, K +-ATPase activity reduction was also abolished by HT (p <0.05). The present study provides evidence of the therapeutic potential of the natural substance hydroxytyrosol in the early stage of diabetic neuropathy.
KW - diabetic neuropathy
KW - hydroxytyrosol
KW - nerve conduction velocity
KW - oxidative stress
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U2 - 10.1021/jf2049323
DO - 10.1021/jf2049323
M3 - Article
C2 - 22594308
AN - SCOPUS:84862180993
VL - 60
SP - 5859
EP - 5865
JO - Journal of Agricultural and Food Chemistry
JF - Journal of Agricultural and Food Chemistry
SN - 0021-8561
IS - 23
ER -