Hydroxytyrosol attenuates peripheral neuropathy in streptozotocin-induced diabetes in rats

Giuseppe Ristagno, Francesca Fumagalli, Carla Porretta-Serapiglia, Alessandro Orrù, Chiara Cassina, Marzia Pesaresi, Serge Masson, Luciano Villanova, Alessandro Merendino, Azzurra Villanova, Luigi Cervo, Giuseppe Lauria, Roberto Latini, Roberto Bianchi

Research output: Contribution to journalArticle

Abstract

Peripheral neuropathy is one of the most frequent and severe complications of diabetes. Hydroxytyrosol (HT), the major antioxidant polyphenolic compound of olive oil, has been investigated as a new potential treatment to counteract the progression of peripheral diabetic neuropathy in rats. An established model of streptozotocin-induced diabetes has been used. After confirmation of hyperglycemia, diabetic and nondiabetic animals were randomized to receive either a low dose or a high dose of HT, or the corresponding vehicle, for 6 weeks. At the end of the 6-week period of treatment, HT blunted plasma thiobarbituric acid-reactive substances increase (p <0.05) and significantly reduced nerve conduction velocity (p <0.05) and thermal nociception impairment in diabetic rats (p <0.05). Sciatic nerve Na+, K +-ATPase activity reduction was also abolished by HT (p <0.05). The present study provides evidence of the therapeutic potential of the natural substance hydroxytyrosol in the early stage of diabetic neuropathy.

Original languageEnglish
Pages (from-to)5859-5865
Number of pages7
JournalJournal of Agricultural and Food Chemistry
Volume60
Issue number23
DOIs
Publication statusPublished - Jun 13 2012

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Keywords

  • diabetic neuropathy
  • hydroxytyrosol
  • nerve conduction velocity
  • oxidative stress

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Chemistry(all)

Cite this

Ristagno, G., Fumagalli, F., Porretta-Serapiglia, C., Orrù, A., Cassina, C., Pesaresi, M., Masson, S., Villanova, L., Merendino, A., Villanova, A., Cervo, L., Lauria, G., Latini, R., & Bianchi, R. (2012). Hydroxytyrosol attenuates peripheral neuropathy in streptozotocin-induced diabetes in rats. Journal of Agricultural and Food Chemistry, 60(23), 5859-5865. https://doi.org/10.1021/jf2049323