Abstract
The effect of repeated treatment with d-fenfluramine, a serotonin releaser, or methergoline, a serotonin antagonist, on [3H]5-HT binding was studied in various rat brain areas. In animals with the same pretreatments, the anorectic activity of m-chlorophenylpiperazine, a serotonin agonist, was investigated. A 14-day treatment with d-fenfluramine caused a significant decrease in the number of [3H]5-HT binding sites (Bmax) in the diencephalon. A reduction of binding sites was found in the cortex too when d-fenfluramine was administered for 28 days. Methergoline caused no changes of [3H]5-HT binding in any brain area exmined when given for 14 days but 28-day treatment led to a significant increase in the striatum, hippocampus and cortex. d-Fenfluramine and methergoline caused, respectively, a decrease and increase in the effect of m-chlorophenylpiperazine on food intake. The data show that central 5-HT receptor numbers and sensitivity may change after repeated treatments with drugs acting on brain serotonin.
Original language | English |
---|---|
Pages (from-to) | 449-457 |
Number of pages | 9 |
Journal | Brain Research |
Volume | 189 |
Issue number | 2 |
DOIs | |
Publication status | Published - May 12 1980 |
Keywords
- apomorphine
- central serotonin receptor
- d-fenfluramine
- food intake
- metachlorophenylpiperazine
- methergoline
- stereotypy
ASJC Scopus subject areas
- Developmental Biology
- Molecular Biology
- Clinical Neurology
- Neuroscience(all)