Hyper- and hyposensitivity of central serotonin receptors: [3H]serotonin binding and functional studies in the rat

R. Samanin, T. Mennini, A. Ferraris, C. Bendotti, F. Borsini

Research output: Contribution to journalArticlepeer-review

Abstract

The effect of repeated treatment with d-fenfluramine, a serotonin releaser, or methergoline, a serotonin antagonist, on [3H]5-HT binding was studied in various rat brain areas. In animals with the same pretreatments, the anorectic activity of m-chlorophenylpiperazine, a serotonin agonist, was investigated. A 14-day treatment with d-fenfluramine caused a significant decrease in the number of [3H]5-HT binding sites (Bmax) in the diencephalon. A reduction of binding sites was found in the cortex too when d-fenfluramine was administered for 28 days. Methergoline caused no changes of [3H]5-HT binding in any brain area exmined when given for 14 days but 28-day treatment led to a significant increase in the striatum, hippocampus and cortex. d-Fenfluramine and methergoline caused, respectively, a decrease and increase in the effect of m-chlorophenylpiperazine on food intake. The data show that central 5-HT receptor numbers and sensitivity may change after repeated treatments with drugs acting on brain serotonin.

Original languageEnglish
Pages (from-to)449-457
Number of pages9
JournalBrain Research
Volume189
Issue number2
DOIs
Publication statusPublished - May 12 1980

Keywords

  • apomorphine
  • central serotonin receptor
  • d-fenfluramine
  • food intake
  • metachlorophenylpiperazine
  • methergoline
  • stereotypy

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

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