Hyper-IgE syndrome: Dental implications

Luca Esposito, Laura Poletti, Cinzia Maspero, Alessandro Porro, Maria Cristina Pietrogrande, Paola Pavesi, Rosa Maria Dellepiane, Giampietro Farronato

Research output: Contribution to journalArticlepeer-review


Hyper-IgE syndrome (HIES) is a rare multisystem disorder with both immunologic and nonimmunological features. It is characterized by extremely elevated IgE serum levels, eczema, and recurrent skin and pulmonary infections. Dental anomalies are often included, such as retention of deciduous teeth together with ectopic eruption or noneruption of permanent teeth. Severe susceptibility to caries and mycotic infections, insufficient transversal diameter of the palate, mucosal plaques, and fissures typically located on the tongue and on the palate are often present. The aim of this study was to review the literature and to report a 6-year observation of 6 patients with HIES (aged 8-39 years) with focus on their oral problems and the treatment provided. The importance of the role of the dentist both in early diagnosis of this syndrome and in monitoring oral conditions was stressed. The dentist can prevent infective complications and intercept the development of malocclusion with a reduction of the need for complex treatment.

Original languageEnglish
Pages (from-to)147-153
Number of pages7
JournalOral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Issue number2
Publication statusPublished - Aug 2012

ASJC Scopus subject areas

  • Surgery
  • Oral Surgery
  • Pathology and Forensic Medicine
  • Radiology Nuclear Medicine and imaging
  • Dentistry (miscellaneous)


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