Abstract
Patients with hyper IgE syndrome (HIES) have varying degree of immunological unbalance that account for deficiency of total T and OKT8 lymphocytes. To investigate the role of immunostimulating drugs in HIES, thymostimulin (TP1) and levamisole were given in highly controlled groups of patients after a wash out period with disodium-chromoglycate (DSCG). Both drugs do not modify clinical picture whereas they do modulate some laboratory parameters as T lymphocyte total number, IgE plasmatic concentration, neutrophil chemotaxis. Furthermore TP1 had a worsening clinical effect in 3 of our patients. In our opinion we feel that the therapies proposed and employed so far for this rare disease must be critically analyzed.
Original language | English |
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Pages (from-to) | 378-382 |
Number of pages | 5 |
Journal | Bollettino dell'Istituto Sieroterapico Milanese |
Volume | 63 |
Issue number | 4 |
Publication status | Published - Sep 1984 |
ASJC Scopus subject areas
- Immunology