Hyper IgE syndrome: four case report.

P. D. Pigatto, M. M. Polenghi, G. F. Altomare, A. M. Brugo, G. L. Tadini, M. Morelli

Research output: Contribution to journalArticlepeer-review


Patients with hyper IgE syndrome (HIES) have varying degree of immunological unbalance that account for deficiency of total T and OKT8 lymphocytes. To investigate the role of immunostimulating drugs in HIES, thymostimulin (TP1) and levamisole were given in highly controlled groups of patients after a wash out period with disodium-chromoglycate (DSCG). Both drugs do not modify clinical picture whereas they do modulate some laboratory parameters as T lymphocyte total number, IgE plasmatic concentration, neutrophil chemotaxis. Furthermore TP1 had a worsening clinical effect in 3 of our patients. In our opinion we feel that the therapies proposed and employed so far for this rare disease must be critically analyzed.

Original languageEnglish
Pages (from-to)378-382
Number of pages5
JournalBollettino dell'Istituto Sieroterapico Milanese
Issue number4
Publication statusPublished - Sep 1984

ASJC Scopus subject areas

  • Immunology


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