Hyperbaric oxygen induced experimental epilepsy: the age factor

C. Masserini, E. Rosina, F. Morosini, A. C. Altamura, C. L. Cazzullo, L. Torcello

Research output: Contribution to journalArticle

Abstract

Two methods of inducing convulsions were used in male Swiss albino mice of different ages: exposure to hyperbaric oxygen and pentylenetetrazole treatment. Hyperbaric oxygen proved to be a valid model of experimental epilepsy with an age-dependent trend. The youngest mice presented a much longer convulsion latency time than the adult mice but the curve of distribution of latency time versus age showed progressively increasing sensitivity. Pentylenetetrazole induced convulsions, apart from the youngest subgroup, without variations by age. Hyperbaric oxygen convulsions provide an interesting model for the study not only of the neurochemistry of convulsions but also of the membrane changes that occur in the course of cerebral maturation and aging.

Original languageEnglish
Pages (from-to)343-348
Number of pages6
JournalItalian Journal of Neurological Sciences
Volume7
Issue number3
DOIs
Publication statusPublished - Jun 1986

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Keywords

  • age
  • brain
  • convulsions
  • Experimental epilepsy
  • hyperbaric oxygen
  • mice
  • pentylenetetrazole

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

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