Hyperbilirubinemia: Does it matter?

Lajos Okolicsanyi, Giulia Martina Cavestro, Claudia Guatti-Zuliani

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Serum bilirubin concentrations are increased in several hematological and hepatic disorders; however, hyperbilirubinemia, often of familial origin, may occur without overt signs of hemolysis or evident liver disease. The authors review briefly the main steps of hepatic bilirubin metabolism, then discuss the pathogenetic mechanisms of the different forms of familial hyperbilirubinemia. The knowledge of these conditions is increasingly important because orthotopic liver transplantation may be a therapeutic choice for some severe forms. Furthermore, early diagnosis is necessary to avoid unnecessary medical investigations for the otherwise relatively common, benign unconjugated hyperbilirubinemia. Finally, individuals with unmasked defective bilirubin handling may be potential liver donors; thus, unexplained jaundice occurring after orthotopic liver transplantation may be related to this disorder.

Original languageEnglish
Pages (from-to)663-668
Number of pages6
JournalCanadian Journal of Gastroenterology
Volume13
Issue number8
Publication statusPublished - Oct 1999

Fingerprint

Hyperbilirubinemia
Bilirubin
Liver Transplantation
Liver
Hemolysis
Jaundice
Liver Diseases
Early Diagnosis
Serum
Therapeutics

Keywords

  • Bilirubin
  • Hyperbilirubinemia
  • Liver disease
  • Orthoptic liver transplantation

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Okolicsanyi, L., Cavestro, G. M., & Guatti-Zuliani, C. (1999). Hyperbilirubinemia: Does it matter? Canadian Journal of Gastroenterology, 13(8), 663-668.

Hyperbilirubinemia : Does it matter? / Okolicsanyi, Lajos; Cavestro, Giulia Martina; Guatti-Zuliani, Claudia.

In: Canadian Journal of Gastroenterology, Vol. 13, No. 8, 10.1999, p. 663-668.

Research output: Contribution to journalArticle

Okolicsanyi, L, Cavestro, GM & Guatti-Zuliani, C 1999, 'Hyperbilirubinemia: Does it matter?', Canadian Journal of Gastroenterology, vol. 13, no. 8, pp. 663-668.
Okolicsanyi L, Cavestro GM, Guatti-Zuliani C. Hyperbilirubinemia: Does it matter? Canadian Journal of Gastroenterology. 1999 Oct;13(8):663-668.
Okolicsanyi, Lajos ; Cavestro, Giulia Martina ; Guatti-Zuliani, Claudia. / Hyperbilirubinemia : Does it matter?. In: Canadian Journal of Gastroenterology. 1999 ; Vol. 13, No. 8. pp. 663-668.
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